摘要
目的探讨子痫前期(PE)孕中期孕妇血清GPⅡb/Ⅲa受体的表达水平变化及对母婴预后的影响。方法选取2016年9月至2018年9月于本院住院分娩的PE患者70例为PE组,对照组为50例正常妊娠妇女。PE组以GPⅡb/Ⅲa受体表达水平中位数为界,分为高GPⅡb/Ⅲa组和低GPⅡb/Ⅲa组各35例。采用流式细胞仪检测血清GPⅡb/Ⅲa受体表达水平。记录和比较各组孕妇的分娩方式、母婴结局。结果PE组GPⅡb/Ⅲa表达显著高于对照组,差异有统计学意义(P<0.05);与低GPⅡb/Ⅲa组、高GPⅡb/Ⅲa组相比,对照组自然分娩率高,剖宫产率低,差异均有统计学意义(P<0.05);与低GPⅡb/Ⅲa组、高GPⅡb/Ⅲa组相比,对照组子痫、凝血异常、心功能不全、肾功能损害等不良妊娠发生率均较低,差异均有统计学意义(P<0.05);低GPⅡb/Ⅲa组、高GPⅡb/Ⅲa组的小早产儿(<34周)、小于胎龄儿发生率高于对照组,差异均有统计学意义(P<0.05)。结论GPⅡb/Ⅲa受体表达水平与母婴不良结局发生率间有关,对PE患者母婴结局的预测具有重要参考价值。
Objective To investigate the changes of expression level of serum GPⅡb/Ⅲa receptor in the second trimester of pre-eclampsia(PE)and its impacts on maternal and infant outcomes.Methods PE patients who were delivered and admitted to our hospital from September 2016 to September 2018 were selected as the PE group(n=70),and normal pregnant women were selected as the control group(n=50).Meanwhile,the PE group was divided into the high GPⅡb/Ⅲa group(n=35)and the low GPⅡb/Ⅲa group(n=35).The expression level of serum GPⅡb/Ⅲa receptor was detected by flow cytometry.The delivery mode and maternal and infant outcomes of pregnant women in each group were recorded and compared.Results The expression of GPⅡb/Ⅲa in the PE group was significantly higher than that in the control group(P<0.05).Compared with the low GPⅡb/Ⅲa group and the high GPⅡb/Ⅲa group,the natural delivery rate of the control group was high,the forceps assisted delivery and cesarean section rate were low,and the differences were statistically significant(P<0.05).Compared with the low GPⅡb/Ⅲa group and the high GPⅡb/Ⅲa group,the incidences of adverse pregnancy events such as eclampsia,abnormal coagulation,cardiac insufficiency and renal function damage in the control group were lower,and the differences were statistically significant(P<0.05).The incidences of premature infants(<34 weeks)and infants younger than gestational age in the low GPⅡb/Ⅲa group and the high GPⅡb/Ⅲa group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The expression level of GPⅡb/Ⅲa receptor is positively correlated with the impacts of maternal and infant adverse outcomes,which is of important reference value for predicting maternal and infant outcomes for PE patients.
作者
刘喜娟
陈安儿
程淑清
蔡海瑞
LIU Xijuan;CHEN Aner;CHENG Shuqing;CAI Hairui(Department of Neonatology,Ningbo Women&Children′s Hospital,Ningbo315012,China;Department of Obstetrics,Ningbo Women&Children′s Hospital,Ningbo 315012,China)
出处
《中国现代医生》
2021年第2期71-74,共4页
China Modern Doctor
基金
浙江省宁波市自然基金项目(2018A610329)。
