摘要
目的比较轻、重型聚丙烯网片植入腹股沟疝修补术后患儿术后疼痛及氧化应激反应的差异。方法前瞻性选择2019年1月至2020年8月亳州市人民医院91例经腹股沟疝修补术治疗的患儿,按随机数字表法分为轻型组(n=45)和重型组(n=46)。其中轻型组患儿给予轻型聚丙烯网片植入腹股沟疝修补术治疗,重型组患儿则给予重型聚丙烯网片植入腹股沟疝修补术治疗。比较2组患儿术后6、12、24、48 h视觉模拟评分(VAS)、氧化应激反应指标[谷胱甘肽S转移酶(GST)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、丙二醛(MDA)]、炎性指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]水平以及并发症发生率。结果术后6、12、24、48 h,轻型组VAS评分分别为(4.85±1.26)、(3.47±1.14)、(2.87±1.03)、(1.08±0.44)分,显著低于重型组[(5.01±0.25)、(4.87±1.22)、(4.44±1.02)、(2.13±0.98)分],差异有统计学意义(P<0.05)。术后轻型组患儿的GST、CAT和SOD活性水平分别为(92.24±9.09)min·mg、(14.36±1.28)min·mg、(9.14±0.77)U/mg,均显著高于重型组[(86.44±9.34)min·mg、(12.21±2.00)min·mg、(8.42±3.41)U/mg],MDA[(5.03±0.43)nmol/mg]水平则显著低于重型组[(5.73±5.55)nmol/mg],差异有统计学意义(P<0.05)。术后轻型组患儿CRP、IL-6和IL-8水平分别为(8.65±3.21)μg/mL、(4.45±1.21)pg/mL、(7.11±2.02)pg/mL,均显著低于重型组[(12.65±3.54)μg/mL、(7.65±3.54)pg/mL、(10.12±4.05)pg/mL],差异有统计学意义(P<0.05)。2组患儿术后并发症总发生率比较,轻型组为4.44%(2/45)显著低于重型组28.36%(13/46),差异有统计学意义(P<0.05)。结论相较于重型聚丙烯网片,轻型聚丙烯网片植入腹股沟疝修补术的优势在于其术后疼痛评分、氧化应激反应水平以及并发症发生率均较低,值得临床广泛推广使用。
Objective To compare the difference of postoperative pain and oxidative stress in children after inguinal hernia repair with light and heavy polypropylene mesh implants.Methods From January 2019 to August 2020,91 children treated with inguinal hernia repair in Bozhou People's Hospital were prospectively selected and divided into light group(n=45)and severe group(n=46)according to a random number table.The light group was given light polypropylene mesh implantation for inguinal hernia repair,while the severe group was given heavy polypropylene mesh implantation for inguinal hernia repair.The visual analogue scale(VAS)at 6,12,24,and 48 h after surgery,levels of oxidative stress response indicators[glutathione S-transferase(GST),catalase(CAT),superoxide dismutase(SOD),malondialdehyde(MDA)],Inflammatory indicators[C-reactive protein(CRP),interleukin-6(IL-6),interleukin-8(IL-8)],and the incidence of complications were compared between the two groups of children.Results At 6,12,24,and 48 h after surgery,the VAS scores of the light group were(4.85±1.26),(3.47±1.14),(2.87±1.03),(1.08±0.44)points,which were significantly lower than those of the severe group[(5.01±0.25),(4.87±1.22),(4.44±1.02),(2.13±0.98)points],the differences were statistically significant(P<0.05).The activity levels of GST,CAT and SOD in the mild group were(92.24±9.09)min·mg,(14.36±1.28)min·mg,and(9.14±0.77)U/mg in the mild group after surgery,which were significantly higher than those in the severe group[(86.44±9.34)min·mg,(12.21±2.00)min·mg,(8.42±3.41)U/mg],MDA[(5.03±0.43)nmol/mg]levels were significantly lower than the severe group[(5.73±5.55)nmol/mg],the differences were statistically significant(P<0.05).The levels of CRP,IL-6 and IL-8 in the mild group were(8.65±3.21)μg/mL,(4.45±1.21)pg/mL,and(7.11±2.02)pg/mL,respectively,which were significantly lower than those in the severe group[(12.65±3.54)μg/mL,(7.65±3.54)pg/mL,(10.12±4.05)pg/mL],the differences were statistically significant(P<0.05).Comparing the total incidence o
作者
贺从涛
罗贤茂
李志锋
HE Cong-tao;LUO Xian-mao;LI Zhi-feng(Department of Pediatric Hernia Abdominal Wall,Bozhou People's Hospital,Bozhou Anhui 236800,China.)
出处
《临床和实验医学杂志》
2021年第4期397-401,共5页
Journal of Clinical and Experimental Medicine
基金
国家卫生计生委医药卫生科技发展项目(编号:W2016EWAH07)。
关键词
腹股沟疝
聚丙烯网片
腹股沟疝修补术
氧化应激
并发症
Inguinal hernia
Propylene mesh
Inguinal hernia repair
Oxidative stress
Complications
