摘要
槐胺碱对心脏具有正性肌力、负性频率、负性自律性和负性传导作用,是槐胺碱抗心律失常的药理学基础。槐胺碱具有降压作用,其降压机制可能与阻断神经节和直接扩张血管有关。由于槐胺碱增强心功能时不增加心肌氧耗量以及具有心肌保护和增加冠脉流量的作用,可以减轻心肌缺血,因此槐胺碱可用于治疗心力衰竭、心肌梗死及各种原因引起的心律失常。槐胺碱还有中枢抑制作用、镇痛抗炎以及免疫抑制作用,可用于治疗移植排斥反应。文中综述国内外学者对槐胺碱药理作用文献报道,并对其药理作用研究进展做了分析。
Sophoramine has positive inotropic action,negative chronotropic action,negative automaticity and negative conductivity on heart,and these actions are its pharmacological basis of antiarrhythmia.Sophoramine has the hypotensive effect,its mechanism may be related to blocking neuroganglia and directly dilating blood vessel.Because sophoramine has the effects of cardioprotection,and enhancing cardiac function and flow of coronary arteria,as well as no enhancing oxygen consumption of myocardium to alleviate myocardial ischemia,so it can treat heart failure,myocardiac infarction,and various arrhythmia.Sophoramine has the effects of central suppression,analgesia,anti-inflammation,and immunosuppression,it can treat transplantation rejection.In this paper,the literatures of the pharmacological effects of sophorine are reviewed,and the research progress of its pharmacological effects is analyzed.
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)
出处
《抗感染药学》
2020年第12期1711-1716,共6页
Anti-infection Pharmacy
关键词
槐胺碱
抗心律失常
中枢抑制作用
抗炎
免疫抑制作用
sophoramine
antiarrhythmia
central suppression
anti-inflammation
immunosuppression
