摘要
目的用一体化PET/MR研究健康年轻男性脑默认网络(DMN)的功能连接(FC)和代谢有效连接(MEC)特征。方法于2019年1月至2019年5月在西安招募15名健康男性受试者(中位年龄29岁),使用PET/MR采集所有受试者全脑的18F-脱氧葡萄糖(FDG)PET、静息功能MRI(fMRI)以及磁化准备快速梯度回波序列(MPRAGE)T1加权数据。使用CONN18b软件和统计参数图(SPM)12进行分析,基于体素提取DMN 4个子网络:内侧前额叶皮质(MPFC)、后扣带回皮质(PCC)及左右两侧的外侧顶叶(LP)的FC及FDG代谢数据,计算FC和MEC并分别进行单样本t检验,统计结果经Bonferroni校正。结果DMN的4个子网络两两之间存在有统计学意义的FC(t值:6.00~7.71,均P<0.008,Bonferroni校正);MPFC与PCC之间(MPFC到PCC:t=10.03,PCC到MPFC:t=3.73,均P<0.004,Bonferroni校正)、双侧LP相互之间(左LP到右LP:t=5.28,右LP到左LP:t=4.76,均P<0.004,Bonferroni校正)存在有统计学意义的双向MEC;MPFC、PCC分别和双侧LP之间存在有统计学意义的单向MEC(t值:3.44~6.93,均P<0.004,Bonferroni校正)。结论DMN内部存在特殊的FC和MEC模式,MPFC和PCC在DMN中较为关键,存在紧密联系且共同调节LP。一体化PET/MR提供了认识脑网络组织形式的新角度,深化了对DMN的全面了解。
Objective To study the functional connectivity(FC)and metabolic effective connectivity(MEC)patterns of the default mode network(DMN)in healthy male adults based on a novel hybrid PET/MR system.Methods Fifteen healthy male adults with median age of 29 years were recruited locally in Xi′an from January to May 2019.All subjects went through PET/MR scan to get the whole brain 18F-fluorodeoxyglucose(FDG)PET,resting-state functional MRI(fMRI)and magnetization prepared rapid gradient echo(MPRAGE)T1 weighted imaging data.CONN18b and statistical parametric mapping(SPM)12 softwares were used to analyze data.The voxel-wise FC and FDG metabolic data were extracted within 4 sub-networks of DMN,which included medial prefrontal cortex(MPFC),posterior cingulate cortex(PCC)and bilateral lateral parietal(LP).The FC and MEC between 4 sub-networks were calculated based on merged resting-state fMRI and metabolic data,and analyzed by one-sample t test separately,with Bonferroni correction.Results FC pathways were all significant within 4 sub-networks of DMN(t values:6.00-7.71,all P<0.008,Bonferroni corrected).Meanwhile,there were significant bi-directional MEC between MPFC and PCC(MPFC to PCC:t=10.03;PCC to MPFC:t=3.73,both P<0.004,Bonferroni corrected),as well as between bilateral LP(LP_L to LP_R:t=5.28;LP_R to LP_L:t=4.76,both P<0.004,Bonferroni corrected).There were significant uni-directional MEC from both MPFC and PCC to bilateral LP(t values:3.44-6.93,all P<0.004,Bonferroni corrected).Conclusions Special FC and MEC patterns exist within DMN.The closely interrelated MPFC and PCC play more important roles in DMN,and they may mediate LP jointly.The novel integrated PET/MR system will bring new perspective on the organization of brain networks,which may deepen the comprehensive understanding of DMN.
作者
王磊
高明
金龙
李云波
袁梦晖
王亚蓉
袁建林
魏龙晓
Wang Lei;Gao Ming;Jin Long;Li Yunbo;Yuan Menghui;Wang Yarong;Yuan Jianlin;Wei Longxiao(Department of Nuclear Medicine,the Second Affiliated Hospital of Air Force Medical University,Xi′an 710038,China;Assisted Reproduction Center,Northwest Women and Children Hospital Affiliated to Xi′an Jiaotong University,Xi′an 710061,China;Department of Radiology,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710061,China;Department of Urology,the First Affiliated Hospital of Air Force Medical University,Xi′an 710032,China)
出处
《中华核医学与分子影像杂志》
CAS
CSCD
北大核心
2021年第2期88-92,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
国家自然科学基金(61971425)
中国博士后科学基金(2019M650985)。
