摘要
整合素家族受体是细胞表面重要的黏附分子,在细胞和微环境之间的相互作用中发挥着重要作用。整合素与多种人类疾病密切相关,如心血管疾病、血栓症、炎症、癌症等,是重要的药物靶点。本文主要论述整合素在心血管疾病中的研究进展。
Integrin family receptors are important adhesion molecules on cell surface and play an important role in the interaction between cells and microenvironment. Integrin is closely related to a variety of human diseases, such as cardiovascular disease, thromboembolism, inflammation, cancer, etc., and is an important drug target. This paper mainly summarizes the research progress of integrin in cardiovascular diseases.
作者
吕慧珍
李侃
艾玎
LYU Huizhen;LI Kan;AI Ding(Department of Physiology and Pathophysiology,Tianjin Medical University&Tianjin Key Laboratory of Metabolic Diseases,Tianjin 300070,China;Hospital of Hematology,Chinese Academy of Medical Sciences&Institute of Hematology,Chinese Academy of Medical Sciences&State Key Laboratory of Experimental Hematology,Tianjin 300020,China)
出处
《中国动脉硬化杂志》
CAS
2021年第2期98-105,共8页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81925003、91849105、82000423)
中国博士后科学基金面上项目(2019M660549)。
关键词
整合素
细胞外基质
心血管疾病
integrin
extracellular matrix
cardiovascular disease
