摘要
Thioxo/dithioxo-naphthalimide is a class of rarely visited fluorophore,first synthesized in 1999.Facile chemistry was devised to achieve mono or dual thionation of the two carbonyl groups of 1,8-naphthalimide.Thionation effectively shifts absorption maximum to longer spectral wavelength,significantly increase absorption coefficients,and dramatically enhances intersystem crossing efficiency with respect to their oxo-analogues.They were first explored as potent photocleavers to induce DNA strand break and novel photosensitizers for photodynamic therapies.In recent years,the unique chemistry of thioxo groups has been harnessed to achieve new applications,such as fluorescent sensors for heave metal ions.These unique photochemical and photophysical characteristics revitalize them intriguing functional molecules to investigate.In this short review,we wish to revisit their first discovery,facile synthesis,and the endeavors on the use of thioxo/dithioxo-naphthalimides for novel chemical and biomedical applications.
基金
the National Natural Science Foundation of China(Nos.21822805 and 21908065)
Shanghai Municipal Science and Technology Commission(No.18DZ1112703)
China Postdoctoral Science Foundation(No.2019M651427)。
