摘要
叶酸又名蝶酰谷氨酸,其本身并没有生理功能,需要在机体内进行一系列的代谢和转化后才能发挥作用,是参与一碳代谢的关键营养素,在基因合成修复和DNA甲基化中起着重要作用,因此被认为与癌症的发生发展有关。叶酸缺乏和代谢障碍可以作为一个解释宫颈癌多因素致病理论的新角度。但目前叶酸和宫颈癌的相关机制研究尚处于初步阶段,尚需进一步的研究阐明叶酸缺乏和代谢障碍在宫颈癌发生发展的分子内机制。近年来叶酸在宫颈癌的预防、诊断和治疗中的研究都有显著的进展,如叶酸补充或强化对宫颈病变的预防和治疗作用的探索,基于叶酸生物化学特性的宫颈筛查新方法,以及叶酸修饰或功能化的新型靶向药物。综述叶酸及其代谢在宫颈癌中的研究进展。
Folic acid,also known as pteroyl glutamate,has no physiological function,which needs a series of metabolism and transformation in the body to play biological role.It is an essential nutrient involved in the one-carbon metabolism pathway,which plays a critical role in the synthesis and repair of genes and DNA methylation,so it is considered to be related to the occurrence and development of cancer.Folic acid deficiency and metabolic disorders could be a new angle to explain the multifactorial pathogenic theory of cervical cancer.However,the research on the related mechanisms of folic acid and cervical cancer is unclear,and further research is needed to clarify the molecular mechanism of folic acid deficiency and metabolic disorders in the occurrence and development of cervical cancer.Folic acid has made significant progress in the prevention,diagnosis and treatment of cervical cancer in recent years,such as the exploration of folic acid supplementation or fortification on the prevention and treatment of cervical lesions,new cervical screening method based on the biochemical properties of folic acid,and novel targeted drugs modified or functionalized by folic acid.This article reviews the research progress of folic acid and its metabolism in cervical cancer.
作者
李元幸
王伟
郝敏(审校)
LI Yuan-xing;WANG Wei;HAO Min(Department of Obstetrics and Gynecology,The Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《国际妇产科学杂志》
CAS
2021年第1期47-50,共4页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(81972452)
国家卫计委公益性行业科研专项(201402010)
山西省重点研发计划项目(201803D31121)
山西省卫计委科研课题(2018GW04)。
关键词
叶酸
代谢
宫颈肿瘤
乳头状瘤病毒科
宫颈上皮内瘤样病变
Folic acid
Metabolism
Uterine cervical neoplasms
Papillomaviridae
Cervical intraepithelial neoplasia
