摘要
Human gene therapy has made significant advances in less than two decades.Within this short period of time,gene therapy has proceeded from the conceptual stage to technology development and laboratory research,and finally to clinical trials for the treatment of a variety of deadly diseases.Cardiovascular disease,cancer,and stroke are leading causes of death worldwide.Despite advances in medical,interventional,radiation and surgical treatments,the mortality rate remains high,and the need for novel therapies is great.Gene therapy provides an efficient approach to disease treatment.Notable advances in gene therapy have been made for genetic disorders,including severe combined immune deficiency,chronic granulomatus disorder,hemophilia and blindness,as well as for acquired diseases,including cancer and neurodegenerative and cardiovascular diseases.However,lack of an efficient delivery system to target cells as well as the difficulty of sustained expression of transgenes has hindered advancements in gene therapy.Ultrasound targeted microbubble destruction(UTMD)is a promising approach for target-specific gene delivery,and it has been successfully investigated for the treatment of many diseases in the past decade.In this paper,we review UTMD-mediated gene delivery for the treatment of cardiovascular diseases,cancer and stroke.
基金
We thank Dr.Leigh Botly for help with the preparation and editing of this review article.The research reported in this article was supported by a Canadian Institutes of Health Research Foundation grant(332652)awarded to R-K.L.
