摘要
目的收集整理并且评价鼻咽癌放疗患者治疗晚期时的并发症发生情况。方法根据RTOG/EORTC晚期放射性发病评分标准,对2012年1月至2017年1月收治的120例采用放疗的鼻咽癌患者施行放疗晚期并发症的评估,并进行前瞻性研究。结果120例患者中,男78例(65%),女42例(35%);年龄11~78岁,平均年龄(49.7±13.5)岁。平均治疗前和治疗后体重指数(BMI)分别为(22.5±4)kg/m2和(19.8±3.2)kg/m2(P<0.05)。平均辐射后期(3.6±3.4)岁。辐射剂量范围为60~76 Gy。110例(96.1%)的肿瘤组织病理结果为未分化61例(50.8%)和低分化49例(40.8%)的鳞状细胞癌。106例(88.3%)的患者处于Ⅲ期和Ⅳ期。对87例患者(72.5%)进行化疗。加入化疗组的平均辐射后生存期低于单独使用放射治疗组[(2.9±2.7)岁vs(5.4±4.4)岁,P<0.05]。最常见并发症是为口干117例(97.5%),其次为听力损伤如99例(内耳82.5%)。加入化疗可显着增加皮肤并发症的严重程度(P<0.05)。并发症的平均数为(6.3±2.2)分。结论每例患者至少有一种并发症,并严重影响患者的生活质量。医务人员应提早意识到这些并发症,以防止病情加重,并长期改善患者的生活质量。
Objective To investigate the late-onset type complications after radiotherapy in patientts with nasopharyngeal carcinoma.Methods The prospective stdy was performed about the late-onset type complications in 120 patients with nasopharyngeal carcinoma who were treated by radiotherapy in our hospital according to the RTOG/EORTC late-stage radiological scoring criteria.Results Of the 120 patients,there were 78 males(65%)and 42 females(35%),with the age range being 11~78yr,and mean age being(49.7±13.5)yr.And the mean body mass index(BMI)before and after treatment was(22.5±4)kg/m2 and(19.8±3.2)kg/m2(P<0.05).The average radiation period was(3.6±3.4)years,and the radiation doses ranged from 60 to 76Gy(mean 69Gy).110 patients(91.6%)had undifferentiated 61 patients(50.8%)and poorly differentiated squamous cell carcinoma 49 patients(40.8%).106 patients(88.3%)were at stageⅢandⅣ.Chemotherapy was performed for 87 patients(72.5%).The mean radiation duration in chemotherapy group was significantly lower than that in radiation therapy group(P<0.05).Moreover the most common complication were dry mouth[117 patients(97.5%)],followed by hearing impairment[99 patients(82.5%)of the inner ear].Combined chemotherapy could significantly increase the severity of skin complications(P<0.05).The mean number of complications was 6.3±2.2(ranging from 1 to 12).Conclusion In this study,every patient has more or less adverse effects to radiation,therefor,doctors need to be aware of these complications to prevent serious complications to improve the life quality of patients.
作者
张丽
康梅
汪义纯
童铸廷
ZHANG Li;KANG Mei;WANG Yichun(The First Affiliated Hospital of Anhui Medical University,Anhui,Hefei 230022,China)
出处
《河北医药》
CAS
2020年第24期3758-3760,3764,共4页
Hebei Medical Journal
基金
国家自然科学基金(编号:国科金计项[2012]29号)。
关键词
鼻咽癌
迟发型并发症
放射治疗
化学疗法
nasopharyngeal carcinoma
late-onset type complications
radiotherapy
chemotherapy
