摘要
目的:探讨中性粒细胞与淋巴细胞比值(NLR)在急性冠脉综合征(ACS)患者危险分层中的价值。方法:选择2018年6月—2020年3月在我院心内科住院的ACS患者94例,检测血常规,计算NLR;ACS患者根据GRACE评分分为低危组、中危组和高危组。随访观察6个月内ACS患者主要不良心血管事件(MACE)发生情况。比较三组间临床资料、MACE发生率和NLR的差异,采用Pearson相关分析评估NLR与GRACE评分的相关性,使用ROC曲线分析NLR和GRACE评分预测ACS患者随访期间发生MACE情况。结果:高危组NLR、MACE发生率显著高于中危组和低危组,中危组NLR、MACE发生率显著高于低危组(均P<0.05)。Pearson相关分析示NLR与GRACE评分呈正相关(r=0.602,P<0.05)。ROC曲线分析显示NLR、GRACE评分可预测ACS患者MACE的发生,其曲线下面积分别为0.774、0.791,两者联合预测ACS患者发生MACE的曲线下面积为0.836,灵敏度为76.5%,特异度为89.1%。结论:NLR可用于ACS患者的危险分层,其联合GRACE评分可提高对ACS患者发生MACE的预测价值。
Objective:To investigate the value of neutrophil to lymphocyte ratio(NLR)in risk stratification of patients with acute coronary syndrome(ACS).Methods:94 ACS patients admitted to the department of cardiology in our hospital from June 2018 to March 2020 were selected.Blood routine examination were performed and NLR were calculated.ACS patients were divided into low risk group,medium risk group and high risk group according to GRACE score.The main adverse cardiovascular events(MACE)of ACS patients were observed within 6 months.The clinical data,MACE incidence and NLR were compared among the three groups.Pearson correlation analysis was used to evaluate the correlation between NLR and GRACE score.ROC curve was used to analyze NLR and GRACE score to predict MACE in ACS patients during follow-up.Results:NLR and the incidence of MACE in high risk group were significantly higher than that in medium risk group and low risk group,NLR and the incidence of MACE in medium risk group were significantly higher than that in low risk group(all P<0.05).Pearson correlation analysis showed that NLR was positively correlated with GRACE score(r=0.602,P<0.05).ROC curve analysis showed that NLR and GRACE could predict the occurrence of MACE in ACS patients,and the area under the curve was 0.774 and 0.791.The area under the curve of NLR combined with GRACE score to predict MACE in ACS patients was 0.836,the sensitivity was 76.5%,and the specificity was 89.1%.Conclusion:NLR can be used for risk stratification of ACS patients,and its combined GRACE score can improve the predictive value of MACE in ACS patients.
作者
付熠
彭湘杭
王蔚浩
林海云
何兰芬
FU Yi;PENG Xianghang;WANG Weihao(Department of Cardiology,Dongguan East Central Hospital,Dongguan City,Guangdong Province 523560)
出处
《医学理论与实践》
2021年第4期547-549,共3页
The Journal of Medical Theory and Practice
基金
广东省东莞市社会科技发展资助项目(2018507150351416)。
