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儿童反复呼吸道感染影响因素分析 被引量:15

Analysis of the influence factors of repeated respiratory tract infection in children
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摘要 目的探讨儿童反复呼吸道感染(RRTIs)的相关影响因素,为儿童RRTIs的有效防治提供依据和策略。方法选择183例RRTIs患儿纳入病例组,85例同期门诊体检健康儿童纳入对照组,对以上所有儿童可能导致RRTIs的相关因素进行临床资料调查,并对血清微量元素铁、锌、钙、铜,血清25-羟维生素D[25-(OH)-D]水平及肺炎支原体(MP)-IgM抗体进行检测,并对两组儿童的结果进行对比,对RRTIs的相关影响因素进行多因素Logistic回归分析。结果病例组中剖宫产、母乳喂养、湿疹、变应性鼻炎、哮喘、被动吸烟、多次使用抗菌药物儿童所占百分比与对照组比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,哮喘、被动吸烟、多次使用抗菌药物为儿童RRTIs的危险因素,母乳喂养为儿童RRTIs的保护因素。病例组血清微量元素铁、锌、钙及血清25-(OH)-D水平均明显低于对照组,MP-IgM抗体阳性率明显高于对照组,差异有统计学意义(P<0.05)。结论积极控制儿童哮喘,远离被动吸烟,避免抗菌药物滥用,尽量母乳喂养,及时合理补充微量元素铁、锌、钙及维生素D制剂,均衡营养,警惕MP感染,并积极规范治疗,对儿童RRTIs的有效防治非常重要。 Objective To explore the influence factors of recurrent respiratory tract infection(RRTIs)in children,and to provide evidence and strategies for the effective prevention and treatment of recurrent respiratory tract infection in children.Methods A total of 183 RRTIs children were selected into case group and 85 healthy children with health physical examination results were included into control group.Clinical data investigation,detection of serum trace element iron,zinc,calcium,copper,serum 25-hydroxyvitamin D[25-(OH)-D]level and mycoplasma pneumoniae(MP)-IgM antibody were performed on all the above children,and the results of the two groups were compared.The related factors of RRTIs were analyzed by multivariate Logistic regression.Results There were significant differences on the percentage of children with cesarean section,breastfeeding,eczema,allergic rhinitis,asthma,passive smoking and multiple use of antibiotics between control group and case group(P<0.05).Multivariate Logistic regression analysis showed that asthma,passive smoking and multiple use of antibiotics were risk factors for recurrent respiratory tract infections in children,and breastfeeding was a protective factor for recurrent respiratory tract infections in children.The serum levels of trace elements iron,zinc,calcium and 25-(OH)-D in case group were significantly lower than those in control group(P<0.05).The MP-IgM antibody positive rate in case group was significantly higher than that in control group(P<0.05).Conclusion It is suggested that promote positive control of childhood asthma,stay away from passive smoking,avoid abuse of antibiotics,as far as possible breastfeeding,reasonable timely supplement trace elements iron,zinc,calcium and vitamin D preparation,balanced nutrition,guard against MP infection and standardize treatment actively for preventing and controlling RRTIs.
作者 范芳 汤丽萍 牛焕红 李迎侠 FAN Fang;TANG Liping;NIU Huanhong;LI Yingxia(Department of Pediatrics,the First Affiliated Hospital of PLA Air Force Military Medical University/Xijing Hospital,Xi′an,Shaanxi 710032,China;Department of Pediatrics,Xi′an Central Hospital,Xi′an,Shaanxi 710003,China)
出处 《检验医学与临床》 CAS 2021年第4期469-472,共4页 Laboratory Medicine and Clinic
关键词 反复呼吸道感染 影响因素 微量元素 肺炎支原体 儿童 recurrent respiratory infection influence factor trace elements mycoplasma pneumoniae child
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