摘要
牙周炎和高脂血症都是较常见的慢性疾病,严重影响人类身心健康,且两种疾病可能会互相影响,加重病情,然而其具体的生物学机制尚未明确。肠道微生态为机体最大最复杂的微生态系统,牙周炎和高脂血症均可导致肠道菌群组成改变。近年来研究证实,肠道菌群可通过自身代谢产物、影响宿主代谢及免疫反应来调节宿主血脂和骨代谢。本文就牙周炎和高脂血症之间,通过导致肠道菌群紊乱而产生交互作用的病理生理机制进行综述,以期为牙周炎和高脂血症之间潜在的关系提供新思路和理论依据。
Periodontitis and hyperlipidemia are common chronic diseases that seriously affect human health.It is reported that there is a positive relationship between them.However,the exact biological mechanisms are still unclear.Intestinal microecosystem is the largest and most complex ecosystem in human body.Multiple studies have confirmed that the gut microbiota can regulate blood lipids and bone metabolism through its own metabolites,affecting host metabolism and immune response.Both periodontitis and hyperlipidemia can cause changes in the composition of intestinal microbiota.This review aims to deliver an overview of the interaction effects of periodontitis and hyperlipidemia via gut microbiota and provide some new ideas and theoretical bases to improve the recognition of relationship between two diseases.
作者
闫福华
黄悦臻
YAN Fuhua;HUANG Yuezhen(Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China)
出处
《口腔医学研究》
CAS
CSCD
北大核心
2021年第2期95-100,共6页
Journal of Oral Science Research
基金
国家自然科学基金(编号:81970939)
江苏省医学创新团队(编号:CXTDB2017014)
南京口腔疾病临床医学研究中心项目(编号:2019060009)。
关键词
牙周炎
高脂血症
肠道菌群
periodontitis
hyperlipidemia
gut microbiota
