摘要
主动脉壁主要由不断更新的细胞和细胞外基质构成。在正常生理状态下,主动脉壁内的细胞和细胞外组分通过调节自身的功能和结构来应对外界血流动力学的改变,增强主动脉管壁应力。如果主动脉的功能和结构发生障碍,将会导致主动脉管壁退化,力学结构受损,出现主动脉瘤和主动脉夹层。过去20年,研究者从基因组学、蛋白组学、表观遗传学、生物力学等角度,剖析主动脉疾病发病的深层机制,旨在挖掘潜在的药物治疗靶点。
The aortic wall is mainly composed of highly dynamic cell components and extracellular matrix.Under the normal physiological settings,aortic cells and extracellular matrix regulate their functions and structure in order to respond to the hemodynamic changes and increase the strength of aortic wall.Compromise in the function and structure of aortic components would result in aortic degeneration,destroy of biomechanical structure,and development of aortic aneurysm or aortic dissection.Over the last 20 years,investigators have been detecting the potential mechanisms of aortic diseases from the view of genetics,proteomics,epigenetics and biomechanics,which might facilitate the development of effective medications.
作者
周旻
符伟国
ZHOU Min;FU Wei-guo(Department of Vascular Surgery,Zhongshan Hospital,Institute of Vascular Surgery,Fudan University,Shanghai 200032,China)
出处
《中国实用外科杂志》
CSCD
北大核心
2021年第1期89-94,共6页
Chinese Journal of Practical Surgery
基金
国家自然科学基金面上项目(No.81970395,81770474)。
关键词
主动脉疾病
基础研究
进展
aortic diseases
basic research
advance
