摘要
目的探讨女性生殖道朗格汉斯细胞组织细胞增生症的临床病理学特征,以加深此病在宫颈等少见部位的认识。方法对1例宫颈LCH进行HE及免疫组化染色,观察其临床病理特征,并复习相关文献。结果患者女性,31岁,确诊为宫颈LCH,镜下朗格汉斯细胞弥漫增生,肿瘤细胞中等大小,细胞质淡粉染,核呈卵圆形,可见核沟,核仁不明显;背景可见较多嗜酸粒细胞及中性粒细胞等聚集,局部形成“嗜伊红微脓肿”,间质微血管及纤维母细胞增生明显。免疫组化:肿瘤细胞弥漫强表达CD1a和S-100,Langerin阴性,组织细胞CD68阳性。结论“纯”女性生殖道LCH极其少见,临床最常表现为瘙痒,可呈丘疹样体征,极易与湿疹、皮炎等皮肤病相混淆,临床及病理医师对女性生殖道LCH应保持警惕,当遇到难治性湿疹或宫颈糜烂等应考虑到是否存在该病可能。
Objective To investigate the clinicopathological features of langerhans cell histiocytosis in the female genital tract in order to recognize Langerhans cell histiocytosis in cervix and other rare position.Methods 1 case of cervical LCH was stained with HE and immunohistochemical staining.The clinicopathological features were observed and related literatures were reviewed.Results A 31-year old female patient was diagnosed as cervical LCH.The Langerhans cell was diffusely hyperplasia,and The tumor cells were medium sized with lightly pigmented cytoplasm.The nucleus were oval with visible nucleolus.Many eosinophils and neutrophils aggregated in tumor background,and local formation of“eosinophilic microabscess”interstitial microvascular and fibroblast proliferation.Immunohistochemistry:Langerhans cells diffuse strongly expressed CD1a and S-100,Langerin negative,and bistiocytes were positive for CD68.Conclusion The“pure”female genital tract LCH was rare,the most common clinical manifestation is pruritus,which may show papule-like signs.LCH can be confused with skin diseases such as eczema and dermatitis.clinical and pathologists should be vigilant about female genital tract LCH and consider whether the disease was existed,When encountering refractory eczema or cervical erosion.
作者
张惠斌
吴荔香
ZHANG Huibin;WU Lixiang(Fujian Maternity and Child Health Hospital,Fuzhou,350001)
出处
《实用癌症杂志》
2021年第1期93-95,共3页
The Practical Journal of Cancer
