miR-212对疾病基因表达调控的研究进展

Research progress of miR-212 on the regulation of diseases gene expression

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摘要 miRNAs是存在于动植物中的一类RNA分子,每一个miRNA可以调节一个或多个基因,具有十分复杂的调节网络。根据现有研究,miRNA至少调节人类1/3的基因。miR-212是一种新发现的miRNA,它的表达在人类某些疾病的发生、发展过程中起到了非常重要的作用,在阐释相关疾病的发病机制、筛选诊断标志物、疾病的治疗、新药研发、判断疾病预后等方面具有巨大的潜在研究价值。本文就miR-212在癌症、心血管疾病、神经退行性疾病等疾病中的作用作一综述,以资临床借鉴。 miRNA is a kind of RNA molecules existing in plants and animals.Each of them can regulate one or several genes,possessing a very complex regulation network.According to the research so far,miRNA regulates one-third of human genes at least.miR-212 is a newly discovered miRNA,its expression plays a very important role in the occurrence and development of human diseases.It has great potential research value in explaining the pathogenesis of related diseases,screening diagnostic markers,treating diseases,developing new drugs and predicting disease prognosis.This paper reviews the effect of miR-212 in cancer,cardiovascular disease,neurodegenerative disease and other diseases for clinical reference.

作者龙富立彭子明冯逢林镛张建玲覃艳新毛德文韦艾凌 LONG Fu-li;PENG Zi-ming;FENG Feng;LIN Yong;ZHANG Jian-ling;QIN Yan-xin;MAO De-wen;WEI Ai-ling(Department of Hepatology,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning530023,China;School of Graduate,Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning530200,China;College of Adult Education,Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning530001,China)

机构地区广西中医药大学第一附属医院肝病科广西中医药大学研究生院广西中医药大学成人教育学院

出处《中国当代医药》 2021年第2期26-29,共4页 China Modern Medicine

基金广西中医药大学自治区重点实验室课题(17-259-49-04)。