摘要
阿尔茨海默病(Alzheimer’s disease,AD)是发生于老年和老年前期,以认知功能进行性下降为特征的中枢神经系统退行性病变。尽管目前研究发现,AD、载脂蛋白E(apolipoprotein E,APOE)基因型、肠道微生物群三者密切相关,但无直接的研究证实晚发型AD最强的遗传风险因子APOE基因型在AD中是如何与肠道菌群相互作用影响的。因此,本文总结近年来相关研究,从AD与APOE基因型,AD与肠道菌群,AD与APOE基因型及肠道菌群相关性三个角度进行阐述,为AD的病因、病理机制、干预措施方面的研究探寻方向。
Alzheimer’s disease(AD)is a degenerative disease of the central nervous system characterized by progressive decline of cognitive function in old age and early old age.Although current studies have found that AD and apolipoprotein E(APOE)genotypes are closely related to gut microbiota,no direct studies have confirmed how APOE genotypes,the strongest genetic risk factor for AD,interact with gut microbiota in AD.Therefore,the current study summarized the relevant reserches in recent years and explored the correlations between AD and APOE genotypes and gut microbiome from three perspectives,including AD/APOE genotypes,AD/gut microbiome,and AD/APOE genotypes/gut microbiome,trying to provide future research direction at the etiology,pathological mechanism,and possible intervention of AD.
作者
付佳佳
邓爱萍
刘焦
杨静
陈雪平
FU Jiajia;DENG Aiping;LIU Jiao;YANG Jing;CHEN Xueping(West China Clinical Medical College,Sichuan University,Chengdu 610041;Outpatient Department of Neurology,West China Hospital of Sichuan University/West China Nursing School of Sichuan University;Department of Neurology,West China Hospital,Sichuan University,China)
出处
《胃肠病学和肝病学杂志》
CAS
2021年第1期1-5,共5页
Chinese Journal of Gastroenterology and Hepatology
