摘要
随着对脑肿瘤治疗方案研究的日益深入以及患者对生存质量要求的不断提高,作为术后常见并发症之一,术后认知功能障碍逐渐受到临床关注。目前认为,包括炎症因子、活性氧、高迁移率族蛋白B1等在内的细胞因子表达异常是其发生的分子机制。由于认知功能的抽象性,为了更好地对术后认知功能障碍进行评定,临床设计了一系列量表,但不同患者如何选用适宜的量表尚无定论。关于术后认知功能障碍的治疗,主要包括药物治疗和非药物治疗,但目前尚处于研究的初级阶段,缺乏临床指南。本文对脑肿瘤患者术后认知功能障碍的原因、分子机制、评估方式以及治疗方案进行了总结,以期为临床提供借鉴。
With the continuous in-depth research on the treatment of brain tumors and the continuous improvement in patients’ requirement of quality of life, as one of common postoperative complications, postoperative cognitive dysfunction(POCD) has gradually attracted more attention. It is currently believed that abnormal expression of cytokines, including inflammatory factors, reactive oxygen species, and high mobility group protein B1, are the molecular mechanism of POCD. Due to the abstractness of cognitive function, in order to better evaluate POCD, a series of scales have been designed clinically. However, how to choose the appropriate approach for different patients is still inconclusive. The treatment of POCD includes drug therapy and non-drug therapy, which is still in the preliminary stage of research and lacks clinical guidelines. This article summarizes the epidemiology, etiology, mechanism, evaluation methods, and treatment options of POCD in patients with brain tumors.
作者
王雅宁
阳天睿
马文斌
WANG Ya-ning;YANG Tian-rui;MA Wen-bin(Department of Neurosurgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)
出处
《协和医学杂志》
CSCD
2021年第1期99-104,共6页
Medical Journal of Peking Union Medical College Hospital
基金
中国医学科学院医学与健康科技创新工程(2016-I2M-2-001)
清华大学-北京协和医院合作专项项目(2019ZLH101)。
关键词
脑肿瘤
手术
认知功能障碍
并发症
brain tumor
operation
cognitive dysfunction
complication
