摘要
目的:研究散癥痛消方加减治疗子宫内膜异位症痛经患者的临床疗效及对血清癌抗原125(CA125)、白细胞介素-6(IL-6)及前列腺素F2α(PGF2α)表达水平的影响。方法:选取宜昌市中医医院从2017年3月至2018年9月收治的子宫内膜异位痛经患者120例作为研究对象,所有患者均经影像学检查确诊子宫内膜异位症且主诉痛经症状。依照入院时间先后顺序将其分为对照组与治疗组各60例。对照组采用散结镇痛胶囊治疗,治疗组用散癥痛消方加减治疗。观察两组患者临床疗效,对比两组中医证候评分治疗前后的变化情况,记录两组患者疼痛改善情况,并检验两组患者血清炎症因子与前列腺素的表达变化,对结果进行统计学分析。结果:治疗组患者临床疗效及中医证候评分改善均优于对照组,且疼痛程度明显低于对照组,差异有统计学意义(P<0.05);血清检验结果显示治疗前后两组患者CA125表达未见明显变化,差异无统计学意义(P>0.05),治疗后IL-6与PGF2α水平治疗组明显低于对照组,差异有统计学意义(P<0.05)。结论:经采用散癥痛消方加减治疗子宫内膜异位症痛能够降低患者的疼痛程度,有效抑制炎症因子的高表达。
Objective:To study the clinical efficacy of modified Sanzheng Tongxiao Formula(散癥痛消方)in the treatment of endometriotic dysmenorrhea and its effect on the serum levels of expressed CA125,interleukin-6(IL-6)and prostaglandin F2α(PGF2α).Methods:There were 120 patients with endometriotic dysmenorrhea hospitalized in Yichang Hospital of Traditional Chinese Medicine from March 2017 to September2018 and selected as the research objects.All patients complained of dysmenorrhea symptoms and werediagnosed as endometriosis by imaging examination.According to the time of admission,the patients were divided into control group and treatment group,60 patients in each group.The control group was treated with Sanjie Zhentong capsule(散结镇痛胶囊),and the treatment group was treated with modified Sanzheng Tongxiao Formula.The clinical effects of the two groups were observed,and changes of traditional Chinese medicine(TCM)symptoms scores were compared.The pain improvement in the two groups was also recorded,and the serum levels of expressed inflammatory factors and prostaglandins were tested.Results:The clinical efficacy and the improvement of TCM symptoms in the treatment group were better than those in the control group,and the degree of pain was significantly lower than that in the control group,with statistical significance between both groups(P<0.05).The serum test results showed that there was no significant difference in the expression of CA125 between the two groups,while the levels of IL-6 and PGF2αin the treatment group were significantly lower than those in the control group,with statistical difference(P<0.05).Conclusion:For patients with endometriotic dysmenorrhea,modified Sanzheng Tongxiao Formula could effectively reduce the pain,and inhibit the high expression of inflammatory factors.
作者
杨丹
YANG Dan(Department of Gynecology,Hospital of Traditional Chinese medicine,Three Gorges University/Yichang Hospital of Traditional Chinese Medicine,Yichang 443000,China)
出处
《山东中医杂志》
2021年第2期140-143,156,共5页
Shandong Journal of Traditional Chinese Medicine
