摘要
应激是生物体对外源或内源刺激的一种非特异的适应性反应,有助于维持机体的内环境稳态和正常的生理活动。当应激反应的程度超过了机体的适应能力时,会诱发多种生理或心理疾病。应激医学以应激反应诱发的各种疾病为研究对象,阐释应激状态下的生理、病理过程及应激损伤机制,并探索应激相关疾病的预防和治疗手段。本文将从应激反应的概念入手,总结近年来关于应激反应在多种生理或病理状态下的调控机制和生物学功能的研究结果,探讨应激医学最新研究进展。
Stress is an nonspecific adaptive response to endogenous or exogenous stimuli,which is commonly applied by organisms to maintain their internal homeostasis and normal physiological functions.When the extent of stress response surpasses the threshold that the organism can adjust to,a variety of physiological or psychological diseases can be induced by stress response.Stress medicine focuses on investigating the mechanisms underlying the development and progression of the diseases induced by stress response,aiming to find ways to prevent and treat stress-related diseases.Here,we will start with an introduction of stress response,then review the recent advances of stress medicine by discussing the latest research advances in the regulatory mechanisms and biological functions of stress response under various physiological or pathological conditions.
作者
黄灿华
HUANG Can-hua(State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China;West China School of Basic Medical Sciences and Forensic Medicine.,Sichuan University,Chengdu 610041,China)
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2021年第1期1-4,共4页
Journal of Sichuan University(Medical Sciences)
基金
国家自然科学基金(No.81821002、No.81790251)
国家重点研发计划(No.2020YFA0509400)
广东省基础与应用基础研究重大项目(No.2019B030302012)资助。
关键词
应激反应
应激医学
应激原
应激损伤
应激相关疾病
Stress response
Stress medicine
Stressor
Stress injury
Stress-related diseases
