摘要
泡沫细胞的形成与积累是动脉粥样硬化的标志,研究发现靶向泡沫细胞的形成在动脉粥样硬化的治疗与预防中具有重要作用。对动脉粥样硬化相关微小RNA(miRNA)的研究表明,miRNA可直接靶向胆固醇代谢中相关蛋白的表达,调节泡沫细胞的形成。且近年来对循环miRNA的研究发现,部分循环miRNA有望成为抑制泡沫细胞形成的新靶点。文章综述了miRNA对泡沫细胞形成各阶段的影响,并讨论了循环miRNA在泡沫细胞形成中的潜在作用。
The formation and accumulation of foam cells is a sign of atherosclerosis.Studies have found that the formation of targeted foam cells plays an important role in the treatment and prevention of atherosclerosis.Studies on atherosclerosis-related microRNA(miRNA)have shown that miRNA can directly target the expression of proteins related to cholesterol metabolism and regulate the formation of foam cells.In recent years,studies on circulating miRNA have found that some circulating miRNA are expected to become new targets for inhibiting the formation of foam cells.This article reviews the effects of miRNA on various stages of foam cell formation,and discusses the potential role of circulating miRNA in foam cell formation.
作者
谭真真
陈晋波
王丹
付斯麒
王婧
郭会彩
马丽杰
TAN Zhenzhen;CHEN Jinbo;WANG Dan;FU Siqi;WANG Jing;GUO Huicai;MA Lijie(Inner Mongolia Medical University,Hohhot,Inner Mongolia 010110,China;the Second Hospital of Shijiazhuang City,Shijiazhuang,Hebei 050017,China;Department of Toxicology,School of Public Health,Hebei Medical University,Shijiazhuang,Hebei 050017,China;Hebei Province Key Laboratory of Environment and Human Health,Shijiazhuang,Hebei 050017,China)
出处
《中国动脉硬化杂志》
CAS
2021年第1期30-36,共7页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助项目(81473292、21976050)
河北省自然科学基金项目(B2018206283)
2020年河北医科大学“大学生创新性实验计划”项目(USIP2020078)。
