摘要
目的探讨经胸骨旁短轴切面行声学微泡联合重组人尿激酶原(PRO-UK)与单纯应用PRO-UK对急诊经皮冠状动脉介入治疗(PCI)回旋支无复流患者近、中、远期心功能的影响。方法选取贵州医科大学附属医院2018年2月至2019年2月急诊入院行PCI回旋支无复流的患者作为研究对象。同意行声学微泡联合PRO-UK治疗的患者56例作为治疗组,同意单纯应用PRO-UK治疗的患者47例作为对照组。记录患者入院时的一般资料,分析患者PCI术后半小时的心肌梗死(MI)溶栓治疗(TIMI)血流评分情况,记录患者住院期间的心功能及主要心血管不良事件(MACE)发生情况,记录术后1周,6、12个月时的心脏超声指标及不良事件发生情况。结果治疗组PCI术后半小时的TIMI血流评分明显优于对照组,差异有统计学意义(P<0.01)。术后1周,6、12个月治疗组的射血分数、左室收缩末内径、左室舒张末内径均优于对照组,差异均有统计学意义(P<0.01)。治疗组术后1周,6、12个月时的MACE总发生率均明显低于对照组,差异均有统计学意义(P<0.05)。术后6个月,治疗组的严重心力衰竭发生率低于对照组,术后12个月,治疗组非致死性MI、严重心力衰竭、顽固性心绞痛发生率均低于对照组,差异均有统计学意义(P<0.05)。结论与单纯应用PRO-UK相比,经胸骨旁短轴切面行声学微泡联合PRO-UK可以明显改善MI后回旋支无复流患者的心功能,降低MI后近、中、远期的MACE总发生率。
Objective To explore the effects of acoustic microbubbles combined with recombinant human pro-urokinase(PRO-UK)through the parasternal short-axis view and PRO-UK alone in the treatment of patients with acute percutaneous coronary intervention(PCI)with no-reflow in the near,medium and long term.Methods Selectting patients from the Affiliated Hospital of Guizhou Medical University from February 2018 to February 2019 who were admitted to the emergency department and underwent PCI with no-reflow of circumflex branch.56 patients who agreed with the treatment of acoustic microbubble combined with PRO-UK were used as the treatment group,and 47 patients who agreed with the treatment of PRO-UK alone were used as the control group.The general information of the patients was recorded when they were admitted to the hospital.The scores of myocardial infarction thrombolytic therapy(TIMI)blood flow score at half an hour after PCI was analyzed,and cardiac function and major adverse cardiovascular events(MACE)were recorded during hospitalization.The results of cardiac ultrasound and adverse events were recorded at 1 week,6 and 12 months after opration.Results The TIMI blood flow score at half an hour after PCI in the treatment group was significantly better than that in the control group,and the difference was statistically significant(P<0.01).At 1 week,6 and 12 months after operation,the ejection fraction,left ventricular end systolic diameter and left ventricular end diastolic diameter of the treatment group were better than those of the control group,and the differences were statistically significant(P<0.01).The total incidence of MACE in the treatment group at 1 week,6 and 12 months after opration was significantly lower than that in the control group,and the differences were statistically significant(P<0.05).At 6 months after opration,the incidence of severe heart failure in the treatment group was lower than that in the control group;at 12 months after opration,the incidence of non-fatal MI,severe heart failure,and refracto
作者
王新斌
司晓云
李伟
石林艳
孙卫红
陈炳秀
WANG Xinbin;SI Xiaoyun;LI Wei;SHI Linyan;Sun Weihong;Chen Bingxiu(Department of Cardiology,Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine,Urumqi,Xinjiang 830000,China;Department of Cardiology,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550004,China)
出处
《现代医药卫生》
2021年第2期177-180,共4页
Journal of Modern Medicine & Health
基金
国家自然科学基金项目(81960047)
贵州省科技计划(黔科合平台人才〔2018〕5608、黔科合支撑〔2019〕2800、黔科合基础〔2019〕1260)
贵州省普通高等学校科技拔尖人才支持计划(黔教合KY字〔2016〕070)
贵阳市科技局科技计划项目(GY2017-34)
新疆医科大学附属中医医院院级课题(ZYY201510)。
关键词
声学微泡
重组人尿激酶原
联合应用
急性心肌梗死
回旋支
不良事件
Acoustic microbubbles
Recombinant human prourokinase
Combined
Acute myocardial infarction
circumflex
Adverse events
