摘要
目的:探讨儿童H3K27M突变型弥漫性中线胶质瘤的MRI特征。方法:回顾性分析9例经手术病理证实的儿童H3K27M突变型弥漫性中线胶质瘤的临床资料及MRI表现。结果:9例病变均位于脑干,8例呈不规则形,1例呈类圆形,边界均清楚;T1WI以低或稍低信号为主(6例混杂低信号,3例稍低信号),T2WI以高或稍高信号为主(6例混杂高信号,3例稍高信号),T2 FLAIR及DWI均呈高信号;增强扫描呈明显不均匀强化1例、轻度不均匀强化1例、花环状强化3例、结节状强化4例。6例合并小囊变坏死,1例出血,均见包绕基底动脉、瘤周轻度水肿。结论:儿童H3K27M突变型弥漫性中线胶质瘤的发病部位、DWI信号特点及强化特点等MRI征象具有一定的特异性,有助于临床诊断。
Objective:To investigate the MRI characteristics of pediatric diffuse midline gliomas with histone H3K27M mutation.Methods:9 patients pathologically diagnosed as pediatric diffuse midline gliomas with H3K27M mutation were systematically collected and their medical history and MRI images were retrospectively analyzed.Results:The MRI findings of pediatric diffuse midline gliomas as following:usually located in brain stem,single irregular lesion with low-intensity or slightly low-intensity signal on T1WI,high-intensity or slightly high-intensity signal on T2WI,high-intensity signal on T2 FLAIR and DWI;usually combining with necrosis and cyst degeneration(6 cases)but not hemorrhage(1 case);usually clear boundary and vessel surrounding;ring-like(3 cases)or tubercular(4 cases)enhancement.Conclusions:There were certain MRI characteristics of pediatric diffuse midline gliomas with histone H3K27M mutation,which can help to diagnose clinically.
作者
陆苑婷
艾斌
刘鸿圣
LU Yuanting;AI Bin;LIU Hongsheng(Department of Radiology,Guangzhou Women and Children's Medical Center,Guangzhou 510120,China)
出处
《中国中西医结合影像学杂志》
2021年第1期75-77,共3页
Chinese Imaging Journal of Integrated Traditional and Western Medicine
基金
广州市妇女儿童医疗中心内部科研基金(YIP-2019-023)
广州市科技计划项目(201804010142)。
