摘要
目的分析新型冠状病毒肺炎(COVID-19)患者的临床特征,为临床诊疗提供参考。方法选取2020年1月29日至2月16日广西壮族自治区南宁市和湖北省武汉市3家定点医院收治的123例确诊为COVID-19的患者为研究对象,其中南宁68例,武汉55例。于入院第1天收集病例资料,对纳入患者的临床特征进行描述性分析,并对南宁地区与武汉地区COVID-19患者进行比较分析。结果(1)COVID-19患者平均年龄(49.0±12.9)岁,轻症105例(85.4%),重症18例(14.6%);男性居多,男女比例为1.2∶1。(2)患者以发热(81.3%)和咳嗽(52.8%)为主要临床表现,其他症状还包括肌肉疼痛(35.0%)、胸闷或气促(23.6%)、咳痰(20.6%)、呼吸困难(3.3%)、腹泻(2.4%)等,少数患者无临床症状(0.8%)。实验室检查中,多数患者白细胞数正常(76.4%)、C-反应蛋白升高(56.1%)、淋巴细胞降低(53.7%),部分患者出现丙氨酸氨基转移酶(ALT)和(或)天门冬氨酸氨基转移酶(AST)升高(19.5%)、白细胞降低(23.6%);少数患者中性粒细胞百分比升高(4.9%)。(3)早期肺部CT主要表现为点状、磨玻璃样改变(54.5%),部分患者无明显改变(45.5%)。(4)与武汉的COVID-19患者相比,南宁患者平均年龄较小(P<0.001),咳痰症状(P<0.001)、淋巴细胞计数降低(P=0.041)较少见,但发热症状更常见(P=0.008)。结论COVID-19患者以发热和咳嗽为主要表现,多数患者白细胞数正常、C-反应蛋白升高、淋巴细胞降低,肺部CT呈点状、磨玻璃样改变,部分患者肝功能受损,极少数患者无症状。与武汉患者相比,南宁患者起病年龄较小,且发热多见。
Objective To analyze the clinical characteristics of patients with 2019 coronavirus disease(COVID-19)and provide reference for clinical diagnosis and treatment.Methods A total of 123 patients with COVID-19 admitted to 3 designated hospitals in Guangxi and Wuhan from January 23,2020 to February 16,2020 were included,of which 68 in Guangxi and 55 in Wuhan.Case data on the first day of admission was collected and descriptive analysis of the clinical characteristics of the included patients was conducted.Patients were compared and analyzed between the 2 areas.Results(1)The average age of patients with COVID-19 was(49.0±12.9)years old,with 105 mild cases(85.3%),18 critical cases(14.7%).Most of them were male,the ratio of male to female was 1.2∶1.(2)Fever(81.3%)and cough(52.8%)were the main clinical manifestations.Other symptoms included muscle soreness(35.0%),chest tightness or shortness of breath(23.6%),expectoration(20.3%),dyspnea(3.3%)and diarrhea(2.4%).Only few patients were asymptomatic(0.8%).In the laboratory examination,most patients had normal leukocytes(76.4%),elevated C-reactive protein(56.1%)and reduced lymphopenia(53.7%),while the alanine aminotransferase(ALT)and/or aspartate aminotransferase(AST)increased(27.3%)and leukopenia(23.6%)in some patients.A few patients had the percentage of neutrophils increased(4.9%).(3)In the early stage of lung CT,most patients werepresented point-like and ground-glass changes(54.5%),and some had no obvious changes(45.5%).(4)Compared with the patients in Wuhan,the average age of the patients in Guangxi was relatively young(P<0.001).Expectoration(P<0.001)or leukopenia(P=0.041)were fewer than those in Wuhan,but fever were more common(P=0.008).Conclusion Fever and cough were the most commonly experienced symptoms of COVID-19 patients.Most patients had normal leukocytes,elevated C-reactive protein,lymphopenia.The main manifestations of lung CT were point-like and ground-glass.Some patients with abnormal liver function and leukopenia.Few patients were asymptomatic.Compared wit
作者
吉攀
朱洁云
李红园
钟枝梅
何翠影
李柏成
张剑锋
JI Pan;ZHU Jieyun;LI Hongyuan;ZHONG Zhimei;HE Cuiying;LI Bocheng;ZHANG Jianfeng(Department of Emergency,the Second Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530007,China)
出处
《重庆医学》
CAS
2021年第1期63-66,共4页
Chongqing medicine
基金
国家自然科学基金项目(81960343)
广西重点研发项目(桂科AB17195002)
广西自然科学基金项目(2017GXNSFAA198249)
广西科技计划项目(桂科AB20058002)。
