摘要
目的分析药物代谢酶和转运体介导的草药-化学药相互作用(herb-drug interactions,HDIs)和不良反应发生机制,总结常用草药与化学药物之间潜在相互作用的信息。方法通过PubMed、Web of Science和中国知网等文献检索数据库,对草药、转运体、代谢酶等关键词进行文献检索。结果草药与化学药合用并不总是有益、安全的,草药可以介导药物代谢酶和转运体的活性来发生HDIs,这会导致一些不良反应发生的潜在风险。结论不恰当的草药与化学药合用会增加化学药不良反应的发生几率,这种草药-化学药介导的相互作用引起的不良反应值得临床医生、制药企业和药品监管部门关注。
Objective To analyze the possible mechanism by which drug metabolizing enzymes and transporters mediate herb-drug interactions(HDIs)and causes of adverse reactions,and summarize the data about potential interactions between commonly used herbs and conventional chemical drugs.Methods Such databases as PubMed,Web of Science and CNKI were searched with"herbs""transporters"and"metabolizing enzymes"as the key words.Results The use of herbs combined with chemical drugs was not always conducive and safe.Herbs can mediate the activity of drug metabolic enzymes and transporters to produce HDIs,which can potentially lead to risks of adverse reactions.Conclusion Inappropriate combination of herbs and drugs will increase the chance of potential adverse reactions,and adverse reactions caused by herb-drug interactions deserve the attention of clinicians,pharmaceutical companies and drug regulators.
作者
王姝廷
邱彩霞
王凤林
靳洪涛
WANG Shuting;QIU Caixia;WANG Fenglin;JIN Hongtao(New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China;Medical Experimental Center,the Third Medical Center of Chinese PLA General Hospital,Beijing 100039,China;China Beijing Union-Genius Pharmaceutical Technology Co.,Ltd.,Beijing 100176,China)
出处
《中国药物警戒》
2021年第1期18-23,共6页
Chinese Journal of Pharmacovigilance
基金
十三五重大新药创制专项(2018ZX09201017-5,2018ZX09711001-002-001):吸入毒性和儿童用药等特色创新药物安全性评价关键技术研究
新技术新方法在药物毒性中的应用
中国毒理学会临床毒理课题(CST2019CT105):基于临床风险信号的毒理学评价路径研究。
关键词
草药
代谢酶
转运体
草药-化学药相互作用
核受体
herb
drug metabolizing enzymes
transporters
herb-drug interactions(HDIs)
nuclear receptor
