摘要
目的:评价肠外营养(PN)个体化治疗对具有营养风险的晚期肺癌病人营养状况、免疫功能及生活质量的影响。方法:110例具有营养风险的晚期肺癌病人随机分为个体化PN组和对照组。两组均接受PN支持治疗,个体化PN组由临床药师开具个体化PN处方进行PN,对照组给予工业化生产的三腔袋进行PN。比较两组治疗前及治疗3周后血清白蛋白、前白蛋白、T淋巴细胞亚群的变化、体质量指数(BMI)和生活质量评分(QOL评分)。结果:治疗3周后,个体化PN组血清白蛋白、前白蛋白、CD4+、CD8+、CD4+/CD8+、BMI和QOL评分均较治疗前和对照组升高(P<0.05)。结论:PN个体化治疗可改善具有营养风险的晚期肺癌病人的免疫功能和生活质量。
Objective:To evaluate the effect of individualized parenteral nutrition(PN)therapy on nutritional status,immune function and quality of life(QOL)in patients with advanced lung cancer and nutritional risk.Methods:A total of 110 patients with nutritional risk of advanced lung cancer were randomly divided into individualized parenteral nutrition group and control group.The patients of the two groups received PN support therapy.Patients in the individualized parenteral nutrition group were given PN prescribed by clinical pharmacists,while patients in the control group were given PN by industrial production of three-chamber bags.The levels of serum albumin,prealbumin,T lymphocyte subsets before and 3 weeks after PN therapy were compared between two groups.The body mass index(BMI)and QOL score were evaluated and compared as well.Results:After 3 weeks of PN treatment,the levels of serum albumin,prealbumin,CD4+,CD8+,CD4+/CD8+,BMI and QOL scores were all increased in the individualized parenteral nutrition group compared with those before PN treatment and those in the control group(P<0.05).Conclusion:The individualized PN therapy can improve immune function and QOL in patients with advanced lung cancer and at nutritional risk.
作者
陈维
杨达宇
孙景存
张学敏
CHEN Wei;YANG Da-yu;SUN Jing-cun;ZHANG Xue-min(Department of Respiratory,Cangzhou Hospital of Integrated Traditional and Western Medicine of Hebei Province,Cangzhou 061000,Hebei,China)
出处
《肠外与肠内营养》
CSCD
北大核心
2020年第6期355-357,362,共4页
Parenteral & Enteral Nutrition
关键词
肠外营养
个体化治疗
晚期肺癌
Parenteral nutrition
Individualized treatment
Advanced lung cancer
