摘要
目的观察养阴利湿方治疗慢性萎缩性胃炎的疗效及对血清胃蛋白酶原(PG)、胃泌素的影响。方法选择2017年5月至2018年12月在上海交通大学医学院附属新华医院崇明分院中医内科、消化内科就诊的80例慢性萎缩性胃炎患者为研究对象,按照治疗方法不同分为观察组和对照组,各40例。观察组患者予自拟方养阴利湿方治疗,每日一剂,分早晚2次口服,每次200 mL;对照组患者予维酶素片治疗,每次4片(0.8 g),每日3次。两组疗程均为3个月。治疗后观察两组患者的症状和体征、胃镜黏膜像、组织病理学变化,检测两组患者治疗前后血清PGⅠ、PGⅡ、胃泌素17(G-17)和前列腺素E 2(PGE 2)水平变化以及不良反应发生情况。结果观察组临床总有效率高于对照组[92.5%(37/40)比75.0%(30/40)](P<0.05),证候总有效率高于对照组[90.0%(36/40)比72.5%(29/40)](P<0.05)。萎缩、肠化生、异型增生评分存在交互作用(P<0.01),两组患者治疗后各项评分降低,观察组低于对照组。PGⅠ、PGⅡ、G-17、PGE 2及PGⅠ/PGⅡ比值存在交互作用(P<0.01),治疗后两组患者血清PGⅠ、G-17、PGE 2及PGⅠ/PGⅡ比值明显升高(P<0.01),观察组高于对照组;PGⅡ水平明显下降,观察组低于对照组(P<0.01)。两组患者在治疗期间均未发生不良反应,血尿粪常规、肝肾功能治疗前后均在正常范围内,未发现异常改变。结论养阴利湿方治疗慢性萎缩性胃炎的临床疗效显著,同时可提高血清PGⅠ和G-17水平。
Objective To observe the curative effect of Yangyin Lishi prescription for chronic atrophic gastritis and its effect on serum pepsinogen and gastrin.Methods A total of 80 patients with chronic atrophic gastritis treated in the Department of Traditional Chinese Medicine and Gastroenterology of Chongming Branch Hospital,Affiliated Xinhua Hospital,Shanghai Jiaotong University from May 2017 to Dec.2018 were included.They were divided into an observation group and a control group according to different treatment methods,each group with 40 cases.The observation group was given the Chinese medicine Yangyin Lishi prescription,one dose a day,orally taken two times in the morning and evening,200 mL each time.The control group was given vitacoenzyme tablets,4 tablets(0.8 g)each time,3 times a day.Both groups were treated for 3 months.After treatment,the symptoms and signs,gastroscopic mucosa image,and histopathological changes of the two groups were observed;the changes of level of serum pepsinogen(PG)Ⅰ,PGⅡ,gastrin 17(G-17)and prostaglandin E 2(PGE 2),as well as the adverse reactions in the two groups were tested.Results The total clinical effective rate in the observation group was higher than that in the control group[92.5%(37/40)vs 75.0%(30/40)](P<0.05).The total effective rate of syndrome in the observation group was higher than that in the control group[90.0%(36/40)vs 72.5%(29/40)](P<0.05).There were interactions among atrophy,intestinal metaplasia and dysplasia scores(P<0.01).After treatment,the scores of patients in both groups were reduced,and those in the observation group were lower than those in the control group.PGⅠ,PGⅡ,G-17,PGE2 and PGⅠ/PGⅡratio had interaction effects(P<0.01).After treatment,serum PGⅠ,G-17,PGE2 and PGⅠ/PGⅡratio were significantly increased in both groups(P<0.01),and the ratio of the observation group was higher than that of the control group.PGⅡlevel decreased significantly,and the observation group was significantly lower than the control group(P<0.01).No adverse reactions
作者
王静
倪建俐
王萍
麻志恒
黄美琴
WANG Jing;NI Jianli;WANG Ping;MA Zhiheng;HUANG Meiqin(Department of Traditional Chinese Medicine,Chongming Branch Hospital,Affiliated Xinhua Hospital,Shanghai Jiaotong University,Shanghai 202150,China;Department of Gastroenterology,Chongming Branch Hospital,Affiliated Xinhua Hospital,Shanghai Jiaotong University,Shanghai 202150,China)
出处
《医学综述》
2021年第2期413-416,F0003,共5页
Medical Recapitulate
基金
上海市崇明区“可持续发展科技创新行动计划”项目(CKY2017-14)。
关键词
慢性萎缩性胃炎
中西医结合疗法
养阴利湿方
Chronic atrophic gastritis
Integrated Chinese and western medicine therapy
Yangyin Lishi prescription
