摘要
自噬是真核细胞清除细胞内聚物及受损细胞器,进而维持细胞内稳态的一种自我保护机制。近年来的研究表明,自噬在细胞衰老的发生发展过程中扮演着重要角色。论文概述了细胞衰老的相关研究,如端粒变化、DNA甲基化改变、自噬等,细胞自噬的发展及形成过程,并进一步描述了自噬对细胞衰老的影响,细胞衰老与自噬共同调控通路中关键蛋白mTOR、SIRT1、p53的作用机制,以及通过雷帕霉素、白藜芦醇、亚精胺药物调控细胞自噬水平等方面的研究,以期为延缓细胞衰老相关研究提供参考。
Autophagy is a self-protection mechanism for eukaryotic cells to remove intracellular aggregates and damaged organelles to maintain cell homeostasis.Recent studies have shown that autophagy plays an important role in the development of cellular senescence.This review summarized recent findings on cell senescence,such as telomere changes,DNA methylation changes,autophagy,etc.This review also described the development and formation process of autophagy,the effect of autophagy on cell aging,and the mechanism of key proteins such as mTOR,SIRT1 and p53 in the common regulation pathway of cell senescence and autophagy.The research on the regulation of autophagy levels by rapamycin,resveratrol and spermidine drugs can provide reference for the research on delaying cell senescence.
作者
薛嘉
谢晓刚
康健
盘婕
权富生
XUE Jia;XIE Xiao-gang;KANG Jian;PAN Jie;QUAN Fu-sheng(Key Laboratory of Animal Biotechnology,Ministry of Agriculture/College of Veterinary Medicine,Northwest A&F University,Yangling,Shannxi,712100,China;Shaanxi Animal Disease Prevention and Control Center,Xi'an,Shaanxi,710000,China;Department of Animal Engineering,Yangling Vocational and Technical College,Yangling,Shaanxi,712100,China)
出处
《动物医学进展》
北大核心
2021年第1期110-115,共6页
Progress In Veterinary Medicine
基金
国家转基因生物新品种培育重大专项项目(2016ZX08007-002)。
