摘要
CD146分子发现于1987年,最初被认为是黑色素瘤标志分子,随后30余年的研究,逐渐揭示了该分子在早期发育、免疫应答、代谢等生理过程,以及在肿瘤、炎症、自身免疫病中的重要作用及机制.目前认为,CD146不仅是一个黏附分子,还是新生血管、T细胞活化和多种肿瘤的标志分子,更是一种细胞膜受体,接受细胞外信号并调控细胞内多种重要信号途径.最近,越来越多的临床研究报道,无论是细胞膜表面的CD146,还是血清和其他体液中的可溶性CD146(soluble CD146,sCD146),都已成为多种疾病诊断和预后评价的重要参考,将成为疾病治疗的新靶点.迄今,全球已有40余株CD146抗体,有些治疗性抗体已进入临床试验阶段.本文全面回顾了CD146的研究历史,分析了当前亟待解决的关键科学问题,展望了其未来临床应用的潜能,以期为全面认识CD146,充分发挥其在疾病诊疗中的价值提供更多借鉴.
CD146 was initially identified as a marker of melanoma in 1987. The research history of more than 30 years revealed its physiological functions in early development, immune response, metabolism, and pathological functions in inflammation,autoimmune diseases, tumor and pregnancy diseases. The understanding of the functional mechanisms of CD146 has also changed from mediating cell migration as an adhesion molecule to receiving extracellular signals and activating various intracellular signaling pathways as a cell membrane receptor. The correlation of CD146 to various diseases, especially its roles in tumors, inspired the application explorations of CD146 in diagnosis, prognosis and targeted therapy of those diseases, some of which has entered the clinical stage. In this review, to understand CD146 in an all-round way and develop its application potential in biomedicine, we comprehensively reviewed and summarized the research history of CD146 and addressed the prospect of the fundamental questions in its research and development.
作者
段红霞
熊朝亮
景林
徐庆吉
刘晶玉
马欣然
王大吉
向建全
何志恒
冯静
阎锡蕴
DUAN HongXia;XIONG ChaoLiang;JING Lin;XU QingJi;LIU JingYu;MA XinRan;WANG DaJi;XIANG JianQuan;HE ZhiHeng;FENG Jing;YAN XiYun(Key Laboratory'of Protein and Peptide Drugs,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China;Department of Otolaryngology,and Institute of Translational Medicine,Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center,Shenzhen,518035,China;Laboratory of Biochemistry,and Molecular Biology,School of Basic Medical Sciences,Southwest Medical University,L uzhou 646000,China;School of Future Technology',University of Chinese Academy of Sciences,Beijing 100049,China;Nanozyme Medical Center,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2020年第12期1339-1387,共49页
Scientia Sinica(Vitae)
