摘要
多聚嘧啶区结合蛋白1(polyrimidine tract binding protein 1,PTBP1)是一种选择性剪接蛋白,通过对Pre-mRNA的选择性剪接以产生多样化的mRNA,从而参与多基因表达的转录调控过程,在肿瘤细胞存活、增殖、转移等过程中发挥重要作用。在不同肿瘤中,PTBP1的表达水平及生物学功能不同,机制之一可能在于其结合的相互作用蛋白不同。另外,PTBP1与神经系统退行性病变、高血压的发病有关,还参与机体免疫及细胞衰老。本文就PTBP1的结构、功能及其与疾病的相关性等方面作一综述。
Polyrimidine tract binding protein 1(PTBP1)is an alternative splicing protein which can produce diverse mRNA through selectively splicing pre-mRNA to mediate transcriptional regulation of multi-genes,thus plays an important role in the survival,proliferation and metastasis of tumor cells.Both the expression level and biological function of PTBP1 are different in various types of malignant tumors,of which one of the mechanisms may lie in the different binding interaction proteins.In addition,PTBP1 is related to neurodegenerative diseases and hypertension,and is also involved in immune system and cell senescence.This paper reviews the structure and function of PTBP1 as well as its relationship to the diseases.
作者
车运诚
曾琼瑶(综述)
张文静(审校)
CHEN Yun-cheng;ZENG Qiong-yao;ZHANG Wen-jing(College of Medical Science,Kunming University of Science and Technology,Kunming 650500,Yunnan Province,China)
出处
《中国生物制品学杂志》
CAS
CSCD
2020年第12期1445-1449,共5页
Chinese Journal of Biologicals
基金
国家自然科学基金项目(81860509)
云南省消化疾病内科研究所内设机构项目(2017NS249,2018NS0265)。
关键词
多聚嘧啶区结合蛋白1
选择性剪接
肿瘤
Polyrimidine tract binding protein 1(PTBP1)
Alternative splicing
Tumor
