摘要
目的:分析儿童药品不良反应(ADR)发生特点,为促进临床合理用药提供参考。方法:采用回顾性分析方法,对2011年4月至2018年12月主动上报的308例有效ADR报告进行统计分析。结果:308例ADR中,男女比例1.59∶1,1~3岁年龄组发生ADR最多(51.62%);给药途径以静脉滴注为主(93.33%);引发ADR最多的药品种类为抗微生物药(59.20%),其中以头孢菌素为主(49.10%);ADR以皮肤及其附件损害最常见(84.07%)。结论:应注意ADR发生的相关因素,尽可能减少ADR的发生,促进临床合理用药。
Objective:To analyze the characteristics of pediatric adverse drug reaction(ADR),so as to provide reference for promotion of rational drug use in clinic.Methods:Retrospective analysis was adopted,statistical analysis was conducted on 308 cases of pediatric ADR from Apr.2011 to Dec.2018.Results:Of the 308 cases of ADR,the ratio of male to female was 1.59∶1,the incidence of ADR was the highest in the age group from 1 to 3 years(51.62%).The main route of administration was intravenous drip(93.33%).The antimicrobial agents were the major cause of ADR in respect of the drug types(59.20%),among which cephalosporin took the lead(49.10%).The injury of skin and its appendants appendages were the most common clinical manifestations of ADR(84.07%).Conclusion:The related factors of ADR should be monitored carefully so that ADR can be reduced and the rational drug use can be promoted.
作者
王彬
黄淑贞
陈聪华
Wang Bin;Huang Shuzhen;Chen Conghua(Haikou Hospital of the Maternal and Child Health,Hainan Haikou 570203,China)
出处
《儿科药学杂志》
CAS
2021年第1期49-52,共4页
Journal of Pediatric Pharmacy
关键词
药品不良反应
儿童
合理用药
adverse drug reactions
children
rational drug use
