摘要新生儿持续肺动脉高压(persistent pulm onary hypertension of the newborn,PPHN)又称持续胎儿循环,1969年首次报道。是由多种病因所导致的新生儿出生后肺循环压力、阻力下降障碍,肺循环压力持续高于体循环压力,回流到心脏的静脉血难以进入肺循环进行氧合,而从心房卵圆孔和(或)动脉导管水平直接流入体循环。
7Weinberger B,Weiss K, Heck DE ,et al. Pharmacologic therapy of persistent puhnonary pertension of the newborn [ J ]. Pharmacol Therap,2001, 89( 1 ) :67. 被引量:1
8Thebaud B,Petit T,de Lagausie P,et al. Altered guanylylcyclase activity in vitro of pulmonary arteries from fetal lambs with congenital diaphragmatic hernia[J]. Am J Respir Cell Mol Boil,2002,27 (1) :42 -47. 被引量:1
9Alano MA, Ngougmna E,Ostrea EM ,et al. Analysis of nonsteroidal antiin flammatory drugs in meeonium and its relation to persistent puhnonary hypertension of the newborn [J]. Pediatrics,2001,107 ( 3 ) : 519 - 552. 被引量:1
10Simonneau G,Galie N ,Rubin LJ, et al. Clinical classification of pulmonary hypertension [J]. J Am Coll Cardiol,2004,43 ( suppl 12 ) :5 - 12. 被引量:1