摘要
1例19岁男性患者因心力衰竭合并多种疾病给予利尿、改善心肌功能、抗感染、保肝等治疗。因心率较快(90~110次/min)给予伊伐布雷定2.5 mg口服、2次/d,心率未见下降(94~110次/min)。服药3 d后,将伊伐布雷定剂量增加至5 mg口服、2次/d,心率缓慢降低。加量3 d后,患者心率71~89次/min。加量第4天,患者食用柚子约200 g。之后患者心率持续降低,加量第6天降至50次/min。考虑患者心动过缓为伊伐布雷定所致,停用该药。停药3 d后,患者心率76~131次/min。患者食用柚子前后心率变化特点提示,柚子与伊伐布雷定可能存在食物-药物相互作用。
A 19‑year‑old male patient received diuretics,cardiac function improvement,anti‑infection,and liver‑protective treatments for heart failure and various co‑existing diseases.Ivabradine 2.5 mg twice daily was given due to his higher heart rate[90‑110 beats per minutes(bpm)],but the heart rate did not decrease(94‑110 bpm).The dose of ivabradine was increased to 5 mg twice daily after 3 days of medication and the heart rate decreased slowly.After 3 days of ivabradine dose‑increase,the heart rate of the patient was 71‑89 bpm.On the 4th day,the patient ate about 200 g of pomelo.After that,his heart rate continued to decrease,which was 50 bpm on the 6th day.Bradycardia caused by ivabradine was considered and the drug was stopped.The heart rate of patient was 76‑131 bpm 3 days after the drug withdrawal.Changes of heart rate of the patient before and after eating the pomelo suggested that there might be food‑drug interaction between pomelo and ivabradine.
作者
周建成
郑萍
Zhou Jiancheng;Zheng Ping(Department of Pharmacy,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Pharmacy,Southern Hospital of Southern Medical University,Guangzhou 510515,China)
出处
《药物不良反应杂志》
CSCD
2020年第12期699-700,共2页
Adverse Drug Reactions Journal
