摘要
目的探讨围术期口服倍他乐克对冠状动脉旁路移植术(CABG)后心功能相关指标的影响,并评估其对心肌保护的作用。方法将86例冠心病行CABG患者分为A组38例(术前至少口服倍他乐克1周以上,并维持至手术当日,术后拔除气管插管后开始口服倍他乐克)和B组48例(围术期不服用倍他乐克)。观察2组术后脑利钠肽(BNP)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)等心功能指标,评估围术期口服倍他乐克对CABG术后心功能改善效果。结果A组术后BNP、CK-MB、cTnI水平低于B组,差异有统计学意义(P<0.05)。2组住院期间均未发生严重并发症。结论围术期口服倍他乐克可以明显改善CABG患者的心功能状态。
Objective To explore the effect of perioperative oral administration of betaloc on cardiac function indexes after coronary artery bypass grafting(CABG)and evaluate its effect on myocardial protection.Methods A total of 86 patients with coronary heart disease undergoing CABG were divided into group A and group B.Thirty-eight patients in group A were orally administrated betaloc at least for more than a week before surgery,and maintained until the day of surgery,oral administration of betaloc after tracheal tube extubation,and another 48 patients in group B were not given perioperative oral administration of betaloc.Cardiac function indexes such as brain natriuretic peptide(BNP),creatine kinase isoenzyme(CK-MB)and cardiac troponin I(cTnI)were observed in the two groups after surgery,and the effect of perioperative oral administration of betaloc in improvement of cardiac function after CABG was evaluated.Results The levels of BNP,CK-MB and cTnI in the group A were significantly lower than those in group B(P<0.05).There were no serious complications in both groups during hospitalization.Conclusion Perioperative oral administration of betaloc can significantly improve cardiac function in patients after coronary artery bypass grafting.
作者
陈骁勇
李杰
CHEN Xiaoyong;LI Jie(Department of Pharmacy,Yancheng City First People′s Hospital in Jiangsu Province,Yancheng,Jiangsu,224000;Department of Cardiothoracic Surgery,Yancheng City First People′s Hospital in Jiangsu Province,Yancheng,Jiangsu,224000)
出处
《实用临床医药杂志》
CAS
2020年第24期98-99,102,共3页
Journal of Clinical Medicine in Practice
关键词
倍他乐克
冠状动脉旁路移植术
心功能
心肌保护
betaloc
coronary artery bypass grafting
cardiac function
myocardial protection
