摘要
脑瘫(CP)是儿童神经功能障碍的重要原因。该疾病严重影响了患儿身心健康,给患儿家庭及社会带来了沉重的负担。CP儿童不同个体间的临床表现存在较大差异,胎儿或婴儿大脑中发生的非进行性损伤的异质性反映在临床上是CP儿童各种症状、体征的并存。了解脑部病变特征与儿童运动功能能力之间的关系、探寻影像学生物标记是脑瘫患儿运动功能恢复、改善预后的关键。而结构磁共振成像是脑瘫诊断和治疗的基础,但只有有限数量的研究能够确定脑瘫儿童基于MR的脑结构损伤与特定神经功能结局之间的关系。在此,本文就儿童脑瘫的运动功能障碍的评估、结构MR对脑瘫的诊断及预测价值等研究进展进行综述,以期为脑瘫诊断、康复及改善预后提供有价值的影像学依据。
Cerebral palsy(CP)is the commonest cause of neurological dysfunction in children.This disease seriously affects the physical and mental health of children and brings a heavy burden to their families and society.The clinical manifestations of CP children vary greatly among individuals.The heterogeneity of non-progressive brain injury in fetus or infant reflects the coexistence of various symptoms and signs in children with CP.Understanding the relationship between the characteristics of brain lesions and children's motor function and exploring imaging biological markers are the key to the recovery of motor function and the improvement of prognosis in CP children.Structural magnetic resonance imaging is the basis for the diagnosis and treatment of cerebral palsy.However,only a limited number of studies can determine the relationship between structural MR-based brain damage and specific neurological outcomes in children with cerebral palsy.In this paper,the evaluation of motor dysfunction in children with CP and the value of structural MR in the diagnosis and prediction of CP are reviewed to provide a valuable imaging basis for the diagnosis,rehabilitation and prognosis of cerebral palsy.
作者
何成
尹羽
刘衡
HE Cheng;YIN Yu;LIU Heng(Department of Radiology,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou Province,China;Department of Medical Imaging,Chongqing University Central Hospital,Chongqing 400014,China)
出处
《中国CT和MRI杂志》
2021年第2期12-16,共5页
Chinese Journal of CT and MRI
基金
国家自然科学基金青年科学基金项目(81901732)
贵州省科技支撑计划(黔科合支撑[2020]4Y122号)
重庆市2020年科卫联合医学科研项目(2020MSXM081)
遵义市科技计划项目[遵义市科合HZ字(2019)109号]。
关键词
脑瘫
结构磁共振成像
运动功能障碍
Cerebral Palsy
Structural Magnetic Resonance Imaging
Motor Dysfunction
