摘要
近年来,越来越多的大型队列研究证实睡眠呼吸暂停与缺血性脑卒中关系密切,其中,阻塞性睡眠呼吸暂停(OSA)与缺血性脑卒中的关系尤为密切。大量文献报道,OSA是缺血性脑卒中发生的独立危险因素,会增加其患病率、死亡率、住院时间及住院次数,使患者预后更差。OSA患者最主要的特点是睡眠时反复发生上气道部分或者完全性呼吸气流中断,进而导致患者频繁发生觉醒、睡眠片段化、间歇性低氧、血液高凝及高碳酸血症等,使患者出现呼吸、循环、代谢、神经、体液等多系统的改变。本文主要就OSA与非心源性缺血性脑卒中的相关性、发病机制、治疗等方面的研究进展进行综述。
In recent years,more and more large cohort studies have confirmed that sleep apnea is closely related to ischemic stroke,especially obstructive sleep apnea(OSA).OSA is not only an independent risk factor for ischemic stroke,but also increases its morbidity,mortality,length of hospital stay and number of hospital stays,which greatly reduces the prognosis of patients.The most important feature of patients with OSA is that the upper airway partially or completely were interrupted,stops the patient's respiratory airflow during sleep,which leads to frequent awakening,fragmented sleep,intermittent hypoxia,hypercoagulable blood,and hypercapnia.Such syndrome caused patients to have multiple changes in breathing,circulation,metabolism,nerves,and body fluids.This article reviews the research progresses on the correlation,pathogenesis and treatment of OSA and noncardiogenic ischemic stroke.
作者
江肖芬
赵红念
Jiang Xiaofen;Zhao Hongnian(Dali University School of Clinical Medicine,Dali City,Yunnan Province,671000,China;Department of Neurology,the First Affiliated Hospital of Dali University,Dali City,Yunnan Province,671000,China)
出处
《现代电生理学杂志》
2020年第4期250-255,共6页
Journal of Modern Electrophysiology
