摘要
目的:了解西安市职业人群非酒精性脂肪性肝病(NAFLD)的患病率及其危险因素,为NAFLD的防治提供参考依据。方法:纳入职业人群6422例,根据是否患有NAFLD分为NAFLD组(2038例)和非NAFLD组(4384例)。比较不同年龄及性别人群NAFLD患病率情况,NAFLD组和非NAFLD组一般资料及生化指标,分析NAFLD危险因素。结果:检出NAFLD患者2038例,总患病率31.73%;男性NAFLD患病率显著高于女性(34.66%与16.47%,P<0.001);女性20~29岁组NAFLD患病率低于其他年龄组(P<0.001);男性不同年龄组间NAFLD患病率比较差异无统计学意义(P>0.05)。NAFLD组男女比例、年龄、收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、腰围均高于非NAFLD组(均P<0.001)。与非NAFLD组相比,NAFLD组空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、同型半胱氨酸(Hcy)及尿酸(UA)升高,高密度脂蛋白胆固醇(HDL-C)降低(均P<0.05)。Logistic回归分析结果提示男性、肥胖(BMI及腰围)、代谢紊乱(血糖、血脂及尿酸水平)是影响NAFLD的独立危险因素。结论:西安市职业人群NAFLD患病率较高,其中男性、肥胖(BMI及腰围)、代谢紊乱(血糖、血脂及尿酸水平)是影响NAFLD的独立危险因素。
Objective:To understand the prevalence and risk factors of nonalcoholic fatty liver disease(NAFLD)among occupational population in Xi’an,and to provide reference basis for the prevention and treatment of NAFLD.Methods:A total of 6422 occupational workers were included and divided into NAFLD group(2038 cases)and non-NAFLD group(4384 cases)according to whether they had NAFLD.The prevalence of NAFLD among people of different ages and genders,the general data and biochemical indicators of NAFLD group and non-NAFLD group were compared.The risk factors of NAFLD were analyzed.Results:A total of 2038 NAFLD patients were detected,with a total prevalence of 31.73%;the prevalence of NAFLD in the male group was significantly higher than that in the female group(34.66%vs.16.47%,P<0.001);the prevalence of NAFLD in women aged 20-29 years was lower than that in other age groups(P<0.001);there was no statistically significant difference in the prevalence of NAFLD among different age subgroups in the male group(P>0.05).The ratio of male to female,age,systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),and waist circumference in the NAFLD group were higher than those in the non-NAFLD group(all P<0.001).Compared with the non-NAFLD group,FBG,TG,TC,LDL-C,Hcy and UA were increased and HDL-C was decreased in the NAFLD group(All P<0.05).The Logistic regression analysis suggested that male,obesity(BMI and waist circumference),and metabolic disorders(blood glucose,blood lipids and uric acid levels)were independent risk factors for NAFLD.Conclusion:The prevalence of NAFLD among occupational groups in Xi’an is high,among which male,obesity(BMI and waist circumference),and metabolic disorders(blood glucose,blood lipids and uric acid levels)are independent risk factors for NAFLD.
作者
刘玲娇
余湘尤
虢小丽
LIU Lingjiao;YU Xiangyou;GUO Xiaoli(Department of Endocrinology and Metabolism,Shaanxi Provincial People’s Hospital,Xi’an 710068,China)
出处
《陕西医学杂志》
CAS
2021年第1期107-110,共4页
Shaanxi Medical Journal
基金
国家自然科学基金资助项目(81700735)。
关键词
非酒精性脂肪性肝病
职业人群
患病率
危险因素
血糖
血脂
Nonalcoholic fatty liver disease
Occupational population
Prevalence
Risk factors
Blood glucose
Blood lipids
