摘要
目的观察含ω-3多不饱和脂肪酸(polyunsaturated fatty acids,PUFAs)的肠内营养对胃癌患者术后营养状况及生活质量的影响。方法选择门诊确诊为单纯性局部进展期胃癌并拟行远端胃癌D2根治术和常规化疗的患者60例,随机分为ω-3 PUFAs肠内营养干预组(ω-3组)和常规肠内营养干预组(对照组)。两组均在术后启动肠内营养时开始干预,持续3个月,比较两组患者干预前和干预结束时的营养状况、炎症指标、生活质量评分等。结果共有52例患者完成研究,ω-3组25例,对照组27例,干预后ω-3组患者血液中ω-3 PUFAs、ω-6 PUFAs浓度较对照组和干预前均显著升高(P<0.01),C反应蛋白显著降低(P<0.05),维生素B12浓度较对照组显著升高(P<0.05),体重、体重指数显著高于对照组(P<0.05),能量和蛋白质摄入、生活质量评分均优于对照组(P<0.01)。结论胃癌患者术后恢复期进行富含ω-3 PUFAs的肠内营养治疗,有助于改善其营养状况,降低炎症反应,提高生活质量。
Objective To observe the effect of enteral nutrition containingω-3 polyunsaturated fatty acids(PUFAs)on the nutritional status and quality of life of patients after radical surgery.Methods A total of 60 locally advanced gastric cancer patients undergoing D2 radical surgery and standard chemotherapy were selected and randomly divided intoω-3 group(receiving enteral nutrition containingω-3 PUFAs)and control group(receiving routine enteral nutrition intervention).The intervention was initiated at the time of postoperative enteral nutrition initiation and lasted for 3 months.Then we compared the nutritional status,inflammation index,quality of life scores before and after the intervention between the two groups.Results 52 patients completed the trial,including 25 in theω-3 group and 27 in the control group.After intervention,the bloodω-3 andω-6 PUFAs levels of theω-3 group were significantly higher and the C-reactive protein were reduced than those of the control group and before intervention(P<0.01),and the concentration of vitamin B12 of theω-3 group was significantly higher than that of the control group(P<0.05).Body weight and body mass index of theω-3 group were significantly higher than those of the control group(P<0.05),and the energy and protein intake,the quality of life scores of theω-3 group were better than those of the control group(P<0.01).Conclusion Enteral nutrition support containingω-3 PUFAs is helpful to improve the nutritional status,reduce the inflammatory response and improve the quality of life of patients with gastric cancer in the recovery period.
作者
刘玉猛
张新胜
刘钊
陶扬
刘鹿
徐庆
张永
刘英华
Liu Yumeng;Zhang Xinsheng;Liu Zhao;Tao Yang;Liu Lu;Xu Qing;Zhang Yong;Liu Yinghua(Department of Nutrition,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)
出处
《中华临床营养杂志》
CAS
CSCD
2020年第3期151-157,共7页
Chinese Journal of Clinical Nutrition
基金
解放军总医院临床科研扶持基金资助(2015FC-TSYS-1034)。
关键词
胃癌
化疗
Ω-3多不饱和脂肪酸
营养状况
Gastric cancer
Chemotherapy
ω-3 polyunsaturated fatty acids
Nutritional status
