摘要
目的:探讨呼伦贝尔地区MTHFR C677T基因多态性与Hcy等相关临床指标的关系。方法:纳入高血压伴高同型半胱氨酸(Hcy)血症203例,根据MTHFR C677T基因不同分型分成CC、CT、TT组,比较三组的人群一般特征、Hcy、空腹血糖、血脂、颈动脉彩超结果及治疗前后Hcy变化有无统计学差异。结果:TT组平均年龄为(53.2±12.6)岁,较其它两组小且存在统计学差异(P<0.05)。TT组Hcy水平相对较高,与CC组、CT组存在统计学差异(P<0.05)。结论:呼伦贝尔地区CT基因型占H型高血压患者中的大多数;TT组患病人群年龄相对更小,Hcy水平相对更高,依叶片可有效降低Hcy水平。
Objective:To explore the relationship between MTHFR C677T gene polymorphism and Hcy and other related clinical indicators in Hulun Buir.Methods:203 cases of hypertension with hyperhomocysteinemia were included and divided into Group CC,Group CT and Group TT according to different genotypes of MTHFR C677T gene,with the general characteristics,Hcy,fasting blood glucose,blood lipids,the results of carotid artery color Doppler ultrasound and changes of Hcy after treatment compared.Results:The mean age of Group TT was(53.2±12.6)years,younger than those of the other two groups,there being statistical difference(P<0.05).The level of Hcy in Group TT was higher than those of the other two groups,there being statistical difference(P<0.05).Conclusion:CT genotypes in Hulun Buir account for the majority of H-type hypertension patients.The age of Group TT is relatively younger and the Hcy level,which can be effectively reduced by enalapril maleate folic acid tablets,is relatively higher.
作者
梁秀文
刘晓慧
LIANG Xiuwen;LIU Xiaohui(Hulun Buir Hospital,Inner Mongolia,Hulun Buir 021000,China;The Second People’s Hospital in Heihe)
出处
《包头医学院学报》
CAS
2020年第11期11-13,44,共4页
Journal of Baotou Medical College
基金
呼伦贝尔市科技计划项目(2016YFC0903100)。
