摘要
目的:探讨自体输血在治疗创伤性颅脑损伤患者中的临床效果,对术后并发症及转归的影响。方法:选取2018年5月至2020年2月创伤性颅脑损伤患者92例为研究对象,随机分为对照组和观察组,每组各46例患者。两组患者均进行输血治疗,对照组患者输注异体血治疗,观察组患者应用自体输血治疗,两组患者治疗后完成3个月随访,比较两组患者的凝血功能、并发症及转归。结果:两组患者治疗后凝血功能均得到改善;观察组患者治疗后凝血功能PT、PT-INR、APTT及FIB水平均高于对照组患者(P<0.05);观察组患者治疗后颅内感染、尿路感染、急性肾损伤及血栓栓塞发生率均低于对照组患者(P<0.05);观察组患者治疗后恢复良好率高于对照组(P<0.05);残疾生存及死亡率均低于对照组(P<0.05)。结论:应用自体输血治疗创伤性颅脑损伤患者可改善患者凝血功能,降低并发症发生率,提高患者治疗转归,值得推广应用。
Objective:To investigate the clinical effect of clinical application of autologous blood transfusion in patients with traumatic brain injury and its influence on postoperative complications and outcomes.Methods:A total of 92 patients with traumatic brain injury from May 2018 to February 2020 were selected as subjects and randomly divided into two groups,each with 46 cases.Both groups were treated with blood transfusion intervention.The control group was treated with allogeneic blood,and the observation group was treated with autologous blood transfusion.The two groups were followed up for 3 months after treatment.The coagulation function,complications and outcome of the two groups were compared.Results:The coagulation function of the two groups was significantly improved after treatment;the coagulation function PT,PT-INR,APTT,and FIB levels of the observation group after treatment were higher than those of the control group(P<0.05);The incidences of intracranial infection,urinary tract,acute kidney injury and thromboembolism after treatment were significantly lower than those of the control group(P<0.05);the observation group had a higher recovery rate after treatment than the control group(P<0.05);the disability survival and mortality were lower than those in the control group(P<0.05).Conclusion:The clinical application of autologous blood transfusion in the treatment of traumatic brain injury patients can improve the blood coagulation function of patients,reduce the incidence of complications,and improve the treatment outcome of patients.It is worthy of popularization and application.
作者
侯晓峰
张安龙
张占阅
邵国
HOU Xiaofeng;ZHANG Anlong;ZHANG Zhanyue;SHAO Guo(Department Neurosurgery of the First Affiliated Hospital of Baotou Medical College,Baotou 014010,China;Institute of Neurosurgical Diseases of Baotou Medical College(Translational Medicine);Engineering Technology Center for Bone Tissue Regeneration and Injury Repair in Inner Mongolia Autonomous Region)
出处
《包头医学院学报》
CAS
2020年第11期4-6,18,共4页
Journal of Baotou Medical College
基金
国家自然科学基金(81660214,81960238)
内蒙古自然科学基金(2019BS08007)
内蒙古卫生厅(201701097)
内蒙古教育厅项目(NJZZ20168)
自治区科技成果转化项目(NM2019BT052)
包头市医药卫生基金(2019Z3008-1)
包头市医学重点学科建设项目(BWXK201910)
包头医学院科学研究基金(BYJJ-YF-2018004,BYJJ-YF-201697,BYJJ-QM 201928)。
关键词
自体输血治疗
创伤性颅脑损伤
凝血功能
术后并发症
治疗转归
Autologous blood transfusion therapy
Traumatic brain injury
Coagulation function
Postoperative complications
Treatment outcome
