摘要
肺炎是指终末气道、肺泡和肺间质的炎症,可由病原微生物、免疫损伤、理化因素、过敏等原因导致。近年来国内外学者常用脂多糖诱导建立肺炎动物模型以模拟肺炎发病情况,但其诱导剂量、建模方法及评价检测指标选择等方面多有不同,故本文对脂多糖诱导肺炎动物模型的相关文献进行检索整理并综述其研究进展,以期为肺炎的发病机制、预防及治疗策略的研究提供一定的参考。
Pneumonia involves the inflammation of terminal airways,alveoli and pulmonary interstitium,and can be caused by pathogenic microorganisms,immune damage,physical and chemical factors,allergies and other conditions.In recent years,many domestic and foreign scholars have used lipopolysaccharide to induce the incidence of pneumonia in animal models.However,there are many differences in these models,including the induction dose,modeling method,and selection of evaluation and detection indicators.Therefore,we sought to review the literature on animal models of lipopolysaccharide-induced pneumonia to provide a reference for the study of the pathogenesis,prevention and treatment of pneumonia.
作者
唐思璇
肖芳
TANG Sixuan;XIAO Fang(Department of Heath Toxicology,Xiangya School of Public Health,Central South University,Changsha 410078,China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2020年第6期864-869,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
湖南省自然科学基金(2019JJ40402)。
关键词
脂多糖
肺炎
动物模型
lipopolysaccharide
pneumonia
animal model
