摘要
新型冠状病毒肺炎已构成全球大流行。其病原体严重急性呼吸综合征冠状病毒2(SARS-CoV-2)传播力强,人群普遍易感。病毒通过细胞受体血管紧张素转换酶2进入靶细胞,经跨膜丝氨酸蛋白酶2激活棘突蛋白,可引起多器官损害。目前尚无特异性治疗药物,但已开展多项评估与研究。当前我国疫情得到有效控制,但境外感染人数迅速增加,境外疫情形势严峻,全球疫情防控工作面临巨大挑战。为有效预防和治疗新型冠状病毒肺炎,本文对新型冠状病毒肺炎的病原学、病理机制、临床表现和治疗药物研发等问题进行了综述。
Coronavirus disease 2019 has become a pandemic.The transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is strong,and the population is generally susceptible.The virus enters target cells via angiotensin-converting enzyme 2 as a cellular receptor.Spike protein is activated by serine protease TMPRSS2.The virus can cause damage to multiple organs,and there are currently no specific drugs for this virus.However,several assessments and studies have been carried out.At present,the epidemic situation in China has been effectively controlled.However,the number of infections abroad has increased rapidly.Therefore,the epidemic situation in foreign countries is still very serious.The global epidemic prevention and control work is facing huge challenges.In order to effectively prevent and treat coronavirus disease 2019,this article reviews the etiology,pathological mechanism,pathological manifestations,and development of therapeutic drugs for coronavirus disease 2019.
作者
朱绮霞
刘青光
李红霞
ZHU Qixia;LIU Qingguang;LI Hongxia(Department of Medical Administration,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;Department of Hepatobiliary Surgery,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2021年第1期103-107,共5页
Journal of Xi’an Jiaotong University（Medical Sciences）
