摘要
结核感染T细胞斑点试验(T-SPOT.TB)是以T细胞介导的细胞免疫应答为基础的检测方法,具有灵敏度和特异度均较高的特点,近年在结核病的诊断中越来越受到临床的重视。本文从T-SPOT.TB的原理,外周血T-SPOT.TB在肺结核、肺外结核、结核潜伏感染中的临床诊断应用,以及体液T-SPOT.TB在临床中的应用等进行综述,以期为临床结核病的实验室诊断提供更多依据或线索。
Tuberculous infection of T cells spot test(T-SPOT.TB)is a detection method based on T cell-mediated immune response,which has the characteristics of higher sensitivity and specificity and therefore receives increasing attention in tuberculosis diagnosis.In order to provide more evidence or clues for laboratory diagnosis of tuberculosis,this paper reviews the principle of T-SPOT.TB,application of peripheral blood T-SPOT.TB in clinical diagnosis of pulmonary tuberculosis,extra-pulmonary tuberculosis and latent tuberculosis infection,and clinical application of body fluid T-SPOT.TB.
作者
张晓梅
黄鹏
ZHANG Xiao-mei;HUANG Peng(Center of Evidence-Based Medicine,School of Public Health,Nanchang University,Nanchang 330006,China;Department of Clinical Laboratory,Shangrao People’s Hospital,Shangrao 334000,China;Jiangxi Province Key Laboratory of Preventive Medicine,Nanchang 330006,China)
出处
《南昌大学学报（医学版）》
CAS
2020年第6期71-75,106,共6页
Journal of Nanchang University：Medical Sciences
基金
江西省卫健委科技计划项目(20167269)。
关键词
结核感染T细胞斑点试验
结核病
诊断
tuberculous infection of T cells spot test
tuberculosis
diagnosis
