摘要
目的:探讨血清肝素结合蛋白(HBP)水平联合中性粒细胞与淋巴细胞比值(NLR)对脓毒症患者预后的评估价值。方法:回顾性分析2018年1月-2020年2月笔者所在医院收治的82例脓毒症患者的临床资料,按照28 d预后结果将其分为存活组(63例)和死亡组(19例)。患者入院后均采集5 ml空腹外周静脉血,测定HBP、NLR。比较两组HBP、NLR,分析HBP、NLR单一与联合检测预测脓毒症患者预后的价值。结果:死亡组HBP、NLR值分别为(25.86±5.84)ng/ml、(19.98±2.16),均高于存活组的(16.45±4.19)ng/ml、(14.32±1.95),差异有统计学意义(P<0.05)。HBP、NLR联合检测预测脓毒症患者预后的ROC曲线下面积(AUC)为0.932,HBP预测脓毒症患者预后的AUC为0.874,NLR预测脓毒症患者预后的AUC为0.842。HBP、NLR联合检测预测脓毒症患者预后的特异度与敏感度分别为98.01%、82.64%,均高于HBP的92.21%、73.89%及NLR的80.42%、69.42%。结论:HBP、NLR是预测脓毒症患者预后的有效指标,联合检测能够提高预测特异度和敏感度,值得推广应用。
Objective:To explore the evaluation value of serum heparin-binding protein(HBP)level combined with neutrophil to lymphocyte ratio(NLR)on the prognosis of patients with sepsis.Method:The clinical data of 82 patients with sepsis admitted in our hospital from January 2018 to February 2020 were retrospectively analyzed.According to the prognosis outcome of 28 d,they were divided into the survival group(63 cases)and the death group(19 cases).After admission,5 ml of fasting peripheral venous blood was collected from all patients to determine HBP and NLR.The HBP and NLR between the two groups were compared,and the prognostic value of HBP and NLR single and combined examinations in patients with sepsis were analyzed.Result:The HBP and NLR values of the death group were(25.86±5.84)ng/ml and(19.98±2.16),which were higher than(16.45±4.19)ng/ml and(14.32±1.95)of the survival group,the differences were statistically significant(P<0.05).The area under the ROC curve(AUC)of the combined examinations of HBP and NLR was 0.932,the AUC of HBP was 0.874,and the AUC of NLR was 0.842.The specificity and sensitivity of combined HBP and NLR examinations to predict the prognosis of sepsis patients were 98.01%and 82.64%,respectively,which were higher than 92.21%,73.89%of HBP and 80.42%,69.42%of NLR.Conclusion:HBP and NLR are effective indicators for predicting the prognosis of patients with sepsis.Combined examinations can improve the specificity and sensitivity of prediction,which is worthy of popularization and application.
作者
王文朱
李艾英
黄辉
WANG Wenzhu;LI Aiying;HUANG Hui(Jiawang People’s Hospital of Xuzhou,Xuzhou 221011,China;不详)
出处
《中外医学研究》
2020年第36期56-58,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
江苏省卫生计生委2018年度医学科研课题项目(H201804)。
