摘要
目的探讨维持性腹膜透析患者的血清25-维生素D[25(OH)D]水平及其相关因素。方法选取2019年4~6月福建医科大学附属闽东医院腹膜透析门诊管理的69例维持性腹膜透析患者。收集患者的性别、年龄、原发病、血清25(OH)D、血红蛋白(HGB)、白蛋白(ALB)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo A1)、载脂蛋白B(Apo B)、血清肌酐(Cr)、血尿素(BUN)、血钙(Ca)、血磷(P)、全段甲状旁腺激素(iPTH)等临床资料进行回顾性分析,并进行相关因素分析。结果69例患者血清25(OH)D水平为(11.90±4.34)ng/mL。以血清25(OH)D<15 ng/mL为维生素D缺乏标准,分为两组,维生素D缺乏组55例(79.7%),血清25(OH)D水平为(10.2±2.7)ng/mL;非缺乏组14例(20.3%),血清25(OH)D水平为(18.7±2.6)ng/mL,处于维生素D不足水平。维生素D缺乏组女性所占比例、TC水平、Apo B水平高于非缺乏组,ALB水平低于非缺乏组,差异有统计学意义(P<0.05);两组的年龄、HGB、TG、HDL-C、LDL-C、Apo A1、Cr、BUN、Ca、P、iPTH等指标比较,差异无统计学意义(P>0.05)。多元线性回归分析显示,ALB水平(β=0.493,P=0.002)和性别(β=-2.989,P=0.004)是25(OH)D水平的独立影响因素。结论维持性腹膜透析患者血25(OH)D水平明显不足,大部分处于缺乏水平,低白蛋白血症者维生素D缺乏更为严重。提示改善腹透患者营养不良有可能减轻维生素D缺乏状态。
Objective To explore the serum levels of 25-vitamin D[25(OH)D]and its related factors in patients with maintenance peritoneal dialysis.Methods A total of 69 patients with maintenance peritoneal dialysis managed by peritoneal dialysis clinic of Mindong Hospital Affiliated to Fujian Medical Universitywere selected from April to June in 2019.Collect the patient′s gender,age,primary disease,serum 25(OH)D hemoglobin(HGB),albumin(ALB),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),Apolipoprotein A1(Apo A1),apolipoprotein B(Apo B),serum creatinine(Cr),blood urea(BUN),blood calcium(Ca),blood phosphorus(P),whole parathyroid hormone(iPTH)And other clinical data for retrospective analysis and relevant factor analysis.Results The serum 25(OH)D level of 69 patients was(11.90±4.34)ng/mL,serum 25(OH)D<15 ng/mL were the standard of vitamin D deficiency,they were divided into two groups,of which 55 cases(79.7%)in vitamin D deficiency group,serum 25(OH)D level was(10.2±2.7)ng/mL;in the non-deficiency group,14 patients(20.3%)had a blood 25(OH)D level of(18.7±2.6)ng/mL.The proportion of women in vitamin D deficiency group,TC level,Apo B level were higher than those in the non-deficiency group,ALB level was lower than those in the non-deficiency group,the differences were statistically significant(P<0.05);there were no significant difference in age,HGB,TG,HDL-C,LDL-C,Apo A1,Cr,BUN,Ca,P,iPTH and other indicators between the two groups(P>0.05).Multiple linear regression analysis showed that ALB level(β=0.493,P=0.002)and gender(β=-2.989,P=0.004)were independent influencing factors of 25(OH)D level.Conclusion The level of 25(OH)D in patients with maintenance peritoneal dialysis is obviously insufficient,most of them are in the lack of level,and the vitamin D deficiency is more serious in patients with hypoalbuminemia.It is suggested that improving malnutrition in patients with peritoneal dialysis may reduce the status of vitamin D deficiency.
作者
林腾强
毛石清
叶晓艺
LIN Teng-qiang;MAO Shi-qing;YE Xiao-yi(Department of Nephrology,Mindong Hospital Affiliated to Fujian Medical University,Fujian Province,Fu′an355000,China)
出处
《中国当代医药》
2020年第36期77-79,共3页
China Modern Medicine
关键词
腹膜透析
维生素D缺乏
血清白蛋白
女性
胆固醇
载脂蛋白B
Peritoneal Dialysis
Vitamin D Deficiency
Serum Albumin
Female
Cholesterol
Apolipoprotein B
