摘要
目的探讨同期鼻腔扩容联合改良悬雍垂腭咽成形术(Han-UPPP,H-UPPP)治疗合并高血压的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清8-异构前列腺素(8-iso-PG)、锰超氧化物歧化酶(MnSOD)水平的影响及临床意义。方法对阻塞平面同时位于鼻腔、腭咽平面的合并高血压的OSAHS患者同期实施鼻腔扩容、H-UPPP手术。全面分析呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO2)、Epworth嗜睡量表(ESS)评分、血压及血清8-iso-PG、MnSOD改善情况。短期随访6个月、长期随访1年。结果患者ESS评分、AHI、LSaO2、8-iso-PG、MnSOD、收缩压、舒张压、平均动脉压,术后6个月、术后1年分别与术前比较,术后6个月、术后1年分别与术前差值之间的比较均有显著性差异(P<0.05)。结论针对阻塞平面位于鼻腔、腭咽平面的合并高血压OSAHS患者同期实施鼻腔扩容联合H-UPPP手术治疗,能明显改善血清中8-Isoprostane、MnSOD水平,缓解机体的氧化应激反应,改善OSAHS相关性高血压,但远期疗效下降明显。
OBJECTIVE To study the effect of nasal expansion and H-UPPP on serum 8-iso-PG and serum MnSOD levels in patients of OSAHS combined with hypertension and its clinical significance.METHODS Nasal cavity dilatation and H-UPPP surgery were performed on patients with OSAHS and hypertension at the same time.Comprehensive analysis of the improvement of AHI,LSaO2,ESS score,blood pressure and serum 8-iso-PG and MnSOD was conducted.The patients were reevaluated at 6 months and one year after operation.RESULTS The patient’s ESS score,AHI,LSaO2,8-iso-PG,MnSOD,systolic pressure,diastolic pressure,mean arterial pressure were compared with those before and 6 months and 1 year after operation respectively,and all the parameters had significant differences(P<0.05).CONCLUSION For those patients with OSAHS and hypertension,who are obstructed in the nasal cavity and the pharyngeal plane,nasal dilatation combined with H-UPPP can significantly improve their serum 8-Isoprostane and MnSOD,relieve oxidative stress in the body,and improve OSAHS-related hypertension,while the long-term efficacy has dropped a lot.
作者
戴国平
陆银萍
吕兰
刘龙斌
刘琪
商黎明
DAI Guoping;LU Yinping;LYU Lan;LIU Longbin;LIU Qi;SHANG Liming(Department of Otolaryngology,Shaoxing Hospital of Zhejiang University,Shaoxing People’s Hospital,Shaoxing,Zhejiang,312000,China;Department of Cardiology,Affiliated Hospital of Shaoxing University(Shaoxing Municipal Hospital),Shaoxing,Zhejiang,312000,China;Clinical laboratory,Shaoxing Hospital of Zhejiang University,Shaoxing People’s Hospital,Shaoxing,Zhejiang,312000,China;Department of Otolaryngology,Affiliated Hospital of Shaoxing University(Shaoxing Municipal Hospital),Shaoxing,Zhejiang,312000,China)
出处
《中国耳鼻咽喉头颈外科》
CSCD
2020年第11期644-647,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词
睡眠呼吸暂停
阻塞性
高血压
耳鼻喉外科手术
氧化应激
Sleep Apnea,Obstructive
Hypertension
Otorhinolaryngologic Surgical Procedures
oxidative stress
