摘要
发展了一个高效、简便合成三联苯类化合物的方法。以氯化钯为催化剂,碳酸钾与三乙胺为碱,无需加入任何配体,在乙醇水溶液中氟磺酸联苯酚酯与芳基硼酸进行Suzuki反应,可高效合成含有多种官能团的三联苯类化合物。该方法操作简便、无需氮气保护,且芳基硼酸自偶联副产物少,有利于产品的分离,为三联苯类化合物的合成提供了一条简便而高效的途径。
An efficient and simple protocol has been developed for the preparation of terphenyls.Using PdCl2 as the catalyst,K2CO3 and Et3N as the base,without adding any ligands,the Suzuki reaction between biphenol fluorosulfonate and aryl boronic acid in ethanol aqueous solution can efficiently generate terphenyls containing multiple functional groups.This coupling reaction protocol is convenient to operate,does not require nitrogen protection,and has few by-products from the self-coupling of aryl boronic acid,which is beneficial to product separation.This method provides a simple and efficient way for the synthesis of terphenyl compounds.
作者
任常玥
陈正军
杨明焱
杨德志
袁泽利
李新民
Ren Changyue;Chen Zhengjun;Yang Mingyan;Yang Dezhi;Yuan Zeli;Li Xinmin(College of Pharmacy,Zunyi Medical University,Zunyi,563000)
出处
《化学通报》
CAS
CSCD
北大核心
2020年第12期1133-1137,1148,1057,共7页
Chemistry
基金
国家自然科学基金项目(81660575,81860611)
贵州省科学技术基金项目(黔科合基础[2018]1187)
贵州省高层次创新型人才培养项目(黔科合平台人才[2020]4104)资助。
