摘要
宫腔粘连患者的子宫内膜基底层受损,纤维组织增生,生育能力受到严重影响。然而,目前对中重度宫腔粘连患者的常规手术治疗术后复发率高且效果差。随着再生医学的发展,外源性移植干细胞治疗宫腔粘连取得了一定的进展,干细胞修复子宫内膜将成为一种新的宫腔粘连的治疗方式。研究表明,子宫内膜中存在干细胞,并且其参与内膜的修复与再生。本文主要对子宫内膜干细胞的研究现状和治疗宫腔粘连的进展进行综述。
Intrauterine adhesions is a gynecological disorder characterized by endometrial basal layer damage and fibrous proliferation,which results in infertility.However,the conventional surgery therapy of intrauterine adhesions has high recurrence rates and poor effects.With the development of regenerative medicine,exogenous transplanted stem cell therapy has obtained certain curative effect on intrauterine adhesions as a new treatment.Numerous studies have demonstrated that the existence of endometrial stem cells can support the tissue maintenance/regrowth.In this review,we provide an overview of the accumulating evidence for the endometrial stem cells.We also discuss the development of endometrial stem cell therapy for intrauterine adhesions.
作者
何文
孙晓溪
He Wen;Sun Xiaoxi(Department of Obstetrics and Gynecology Hospital Affiliated to Fudan University,Shanghai 200011,China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2020年第11期939-942,共4页
Chinese Journal of Reproduction and Contraception
关键词
子宫内膜干细胞
宫腔粘连
子宫内膜再生
干细胞治疗
Endometrial stem cells
Intrauterine adhesions
Endometrial regeneration
Stem cell therapy
