摘要
目的探讨药物涂层球囊应用于冠状动脉小血管病变患者中的效果。方法抽取该院2017年1月-2019年10月收治的76例冠状动脉小血管病变患者作为观察对象,随机数字法分为对照组与观察组,两组38例。对照组患者实施支架植入,观察组患者实施药物涂层球囊治疗,观察两组患者治疗后即刻靶病变最小管腔直径改善情况,术中X线辐射剂量情况,平均住院时间及恢复时间,随访6个月不良反应发生情况。结果治疗前后,两组患者的靶病变参考血管直径及术后即刻最小管腔直径对比,差异无统计学意义(P>0.05);治疗后,随访6个月对照组患者心血管不良事件发生率明显高于观察组(15.79%vs 0.00%),差异有统计学意义(χ2=4.524,P<0.05)。对照组患者消化道大出血发生率明显高于观察组(18.42%vs 0.00%),差异有统计学意义(χ2=5.665,P<0.05);对照组患者牙龈或皮肤小出血发生率明显高于观察组(21.05%vs 2.63%),差异有统计学意义(χ2=4.537,P<0.05)。英文摘要治疗后,两组患者的平均住院时间及恢复时间对比,差异无统计学意义(P>0.05);术中观察组患者所受X线辐射剂量明显低于对照组,差异有统计学意义(t=2.823,P=0.003<0.05)。结论药物涂层球囊治疗冠状动脉小血管病变患者作用显著,降低患者靶病变的最小管腔直径及面积方面不劣于支架植入,和支架植入相比,药物涂层球囊疗法可减少所受X线辐射剂量,降低不良事件发生率,值得推广。
Objective To investigate the effect of drug-coated balloons in patients with coronary artery disease.Methods A sample of 76 patients with coronary small vessel disease admitted to the hospital from January 2017 to October 2019 as observation objects.They were randomly divided into control group and observation group,with 38 cases in each group.The control group received stent implantation,the observation group were treated with drug-coated balloons.Observed the improvement of the minimum lumen diameter of the target lesion immediately after treatment in the two groups of patients,the intraoperative X-ray radiation dose,the average hospital stay and recovery time,and the occurrence of adverse reactions for 6 months of follow-up.Results Before and after treatment,there was not statistically significant difference in the reference vessel diameter of the target lesion between the two groups of patients and the smallest lumen diameter immediately after the operation(P>0.05).After treatment,the incidence of adverse cardiovascular events in the control group was significantly higher than that in the observation group(15.79%vs 0.00%),and the difference was statistically significant(χ^2=4.524,P<0.05).The incidence of gastrointestinal bleeding in the control group was significantly higher than that in the observation group(18.42%vs 0.00%),and the difference was statistically significant(χ^2=5.665,P<0.05);the incidence of small gum or skin bleeding in the control group was significantly higher than the observation group Group(21.05%vs 2.63%),the difference was statistically significant(χ^2=4.537,P<0.05).After treatment,there was not statistically significant difference in the average hospital stay and recovery time between the two groups of patients(P>0.05).The X-ray radiation dose received by patients in the observation group during operation was significantly lower than that in the control group,and the difference was statistically significant(t=2.823,P=0.003<0.05).Conclusion The drug-coated balloon has a significant e
作者
李征
LI Zheng(Department of Cardiology,Xuzhou Cancer Hospital(Xuzhou Third People's Hospital),Xuzhou,Jiangsu Province,221000 China)
出处
《系统医学》
2020年第23期58-60,共3页
Systems Medicine
