摘要
目的探讨柴胡加龙骨牡蛎汤加减联合地西泮对肝郁型失眠患者睡眠质量的影响。方法选取2017年5月至2018年8月沈阳二四五医院收治的肝郁型失眠患者100例作为研究对象,根据盲抽法将其分为观察组与对照组,各50例。对照组给予地西泮片口服治疗,观察组在对照组基础上采用柴胡加龙骨牡蛎汤加减治疗。比较两组睡眠质量、临床疗效、不良反应及中医证候积分。结果治疗后,两组睡眠时间提升,入睡时间、觉醒次数及匹兹堡睡眠质量指数量表(PSQI)评分下降,且观察组上述指标改善显著,差异有统计学意义(P<0.05);治疗后,观察组治疗有效率96.00%高于对照组76.00%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗后,两组多梦易醒、入睡困难证候积分均降低,且观察组评分低于对照组,差异有统计学意义(P<0.05)。结论柴胡加龙骨牡蛎汤加减联合地西泮可有效改善肝郁型失眠症患者睡眠质量,提升治疗效果,且用药安全性较高。
Objective To explore the effect of modified Chaihu and Longgu Muli Decoction combined with diazepam on sleep quality of insomnia patients with liver depression. Methods From May 2017 to August 2018, a total of 100 patients with insomnia of liver depression type admitted to Shenyang 245 Hospital were selected as the research objects and were assigned into an observation group and a control group, with 50 cases in each group. The control group was treated with diazepam tablets, and the observation group was treated with modified Chaihu and Longgu Muli Decoction on the basis of the control group. Sleep quality, clinical effect, adverse reactions and Traditional Chinese medicine syndrome points of the 2 groups were compared. Results After treatment, the sleep time of the 2 groups increased, the sleep time, the number of wakes and PSQI scores decreased, and the above indicators of the observation group improved significantly, the difference was statistically significant(P<0.05);after treatment, the total effective rate of the observation group was 96.00% higher than 76.00% of the control group, the difference was statistically significant(P<0.05);the total adverse reactions of the 2 groups were not significantly different(P>0.05). After treatment, the scores of the syndromes of multiple dreams, easy awakening and difficulty falling asleep were reduced in the 2 groups, and the scores of the observation group were lower than those of the control group, the difference was statistically significant(P<0.05). Conclusion Modified Chaihu and Longgu Muli Decoction combined with diazepam can effectively improve the sleep quality of insomnia patients with liver depression, improve the treatment effect, with high drug safety.
作者
张慧
ZHANG Hui(Department of Traditional Chinese Medicine,Shenyang 245 Hospital,Shenyang 110000,China)
出处
《中国药物经济学》
2020年第11期110-112,共3页
China Journal of Pharmaceutical Economics
关键词
肝郁型
失眠
柴胡加龙骨牡蛎汤加减
地西泮
睡眠质量
Liver depression type
Insomnia
Modified Chaihu Longgu Muli Decoction
Diazepam
Sleep quality
