摘要
目的比较氨磺必利、齐拉西酮治疗女性精神分裂症患者的疗效及对QTc间期的影响。方法68例女性精神分裂症患者随机给予氨磺必利或齐拉西酮组治疗8周,比较两组阳性和阴性症状量表(PANSS)评分、心电图QTc间期、疗效及不良反应。结果两组疗效、PANSS评分差异无统计学意义(P>0.05),但氨磺必利组QTc间期及震颤、闭经发生率高于齐拉西酮组(P<0.05)。结论齐拉西酮治疗女性精神分裂症患者的疗效与氨磺必利相当,但不良反应发生率较低,对QTc间期影响较小。
Objective To compare the efficacy of amisulpride versus ziprasidone in female schizophrenia and their effect on QTc interval.Methods Sixty-eight female patients with schizophrenia were randomly treated with amisulpride or ziprasidone for 8 weeks.Clinical efficacy,positive and negative symptom scale(PANSS),QTc interval,and adverse reactions were compared between two groups.Results Clinical efficacy and PANSS scores were comparable between two groups(P>0.05),while QTc interval and incidence of tremor and amenorrhea were higher in amisulpride group than in ziprasidone group(P<0.05).Conclusion Clinical efficacy of ziprasidone is similar to that of amisulpride in female schizophrenia,but its adverse reactions and effect on QTc interval are less.
作者
张德峰
彭宙
陈泽元
吴志雄
马玉桂
陈涛
ZHANG De-feng;PENG Zhou;CHEN Ze-yuan;WU Zhi-xiong;MA Yu-gui;CHEN Tao(Zhanjiang Third People's Hospital,Zhanjiang 524012,China)
出处
《广东医科大学学报》
2020年第6期747-749,共3页
Journal of Guangdong Medical University
